{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:50:10Z","timestamp":1791982210296,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016056"],"award-info":[{"award-number":["P30CA016056"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001320","name":"Roswell Park Comprehensive Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral potentially malignant disorder (OPMD) prognostication is limited by uncertainty of which lesions will progress and the aggressiveness of lesion progression. We defined patterns and kinetics of progression in a large cohort of OPMD subjected to serial clinical and histologic examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 24\u2010year study evaluated the pattern of disease progression in 668 patients with 1313 OPMDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The disease progression pattern was grouped as (a) non\u2010progressive (82.5%), (b) progressive, where initial low\u2010grade dysplasia advanced to high\u2010grade dysplasia in subsequent lesions (5.8%), and (c) transformed, where dysplastic lesions transformed into squamous cell carcinoma (11.7%). Progression showed aggressive (&lt;\u20092\u2009years) and indolent (&gt;\u20092\u2009years) patterns. An aggressive course occurred in 48.3% of progressive and 57.6% of transformed lesions. Progression was associated with high\u2010grade lesions, floor of mouth and palate subsites, and tobacco and alcohol use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data from this study may be used to develop a risk\u2010stratified approach for OPMD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70284","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:41:00Z","timestamp":1777516860000},"page":"2800-2809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pattern of Progression of Oral Potentially Malignant Disorders From Real\u2010World Data: A 24\u2010Year Study"],"prefix":"10.1002","volume":"48","author":[{"given":"Subin","family":"Surendran","sequence":"first","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumsum P.","family":"Sunny","sequence":"additional","affiliation":[{"name":"Integrated Head and Neck Oncology Research Program, Mazumdar Shaw Medical Foundation, Narayana Health  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi M.","family":"Chathoth","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Magner","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lynn","family":"Sigurdson","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Merzianu","sequence":"additional","affiliation":[{"name":"Department of Pathology Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Sule","sequence":"additional","affiliation":[{"name":"Department of Pathology Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly E.","family":"Wooten","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"McSpadden","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amritha","family":"Suresh","sequence":"additional","affiliation":[{"name":"Integrated Head and Neck Oncology Research Program, Mazumdar Shaw Medical Foundation, Narayana Health  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Z.","family":"Samuel","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen N.","family":"Birur","sequence":"additional","affiliation":[{"name":"Integrated Head and Neck Oncology Research Program, Mazumdar Shaw Medical Foundation, Narayana Health  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Wesley L.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive 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