{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:51:53Z","timestamp":1791982313299,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>GLP\u20101 receptor agonists carry an FDA boxed warning for medullary thyroid carcinoma (MTC) risk, though conflicting clinical evidence has generated tremendous controversy regarding this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed SEER and FAERS databases to compare MTC and papillary thyroid cancer (PTC) reporting proportions (RP) between the general population and GLP\u20101RA users (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109\u2009168), controlling for surveillance bias by comparing against other endocrine and non\u2010endocrine drugs. Negative binomial regression was used to estimate the incidence rate ratios (IRR) in the FAERS dataset among patients with reported AEs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 10\u2010year mean MTC RP in SEER\/FAERS was 0.0002%\/0.0014%, while PTC was 0.012%\/0.0087%. Strikingly, GLP\u20101RA users showed increased RPs as compared to the total FAERS RPs: MTC 0.071% (50.7\u2010fold increase) and PTC 0.164% (18.9\u2010fold increase) with significantly elevated IRRs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001) compared to reference groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GLP\u20101RAs showed a higher RP for MTC compared to other drug classes, warranting prospective studies to investigate further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70286","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:38:16Z","timestamp":1776663496000},"page":"2693-2703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Calculating Glucagon\u2010Like Pepide\u20101 Receptor Agonist\u2010Associated Medullary Thyroid Cancer Risk: A Novel Integration of the Surveillance, Epidemiology and End Results Cancer Registry and the\n                    <scp>FDA<\/scp>\n                    Adverse Event Reporting System"],"prefix":"10.1002","volume":"48","author":[{"given":"Stella J.","family":"D'Arcy","sequence":"first","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9263-7206","authenticated-orcid":false,"given":"Sophia L.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerin A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husneara","family":"Rahman","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Biostatistics Unit, Office of Academic Affairs  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sison","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dev","family":"Kamdar","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Department of Otolaryngology Long Island Jewish Medical Center  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Periera","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Department of Otolaryngology Long Island Jewish Medical Center  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-6172","authenticated-orcid":false,"given":"Brett","family":"Miles","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Department of Otolaryngology Long Island Jewish Medical Center  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Frank","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"name":"Department of Otolaryngology Long Island Jewish Medical Center  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagashree","family":"Seetharamu","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"name":"Department of Medicine Long Island Jewish Medical Center  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charit","family":"Taneja","sequence":"additional","affiliation":[{"name":"Northwell  New Hyde Park New York USA"},{"name":"Department of Medicine Long Island Jewish Medical Center  New Hyde Park New York 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