{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:49:40Z","timestamp":1791982180443,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with HPV+ oropharyngeal cancer (OPC) have worse outcomes with longer smoking history (\u2265\u200910 pack\u2010years). This has been confirmed in trials of primary radiotherapy but not surgery, suggesting differential smoking impact by treatment received. We assessed smoking\u2010related outcomes at a single institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Kaplan\u2013Meier and Cox proportional hazards regression compared &lt;\u200910 versus \u2265\u200910 pack\u2010years by treatment received for progression\u2010free survival (PFS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Smoking was associated with worse PFS in both primary (chemo)radiation (HR\u2009=\u20091.73 [1.12\u20132.69],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and primary surgery cohorts (HR\u2009=\u20091.77 [1.02\u20133.07],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). In surgery patients, this association was attenuated after adjusting for socioeconomic indicators (HR\u2009=\u20091.69 [0.97\u20132.93],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06). On recursive partitioning analysis\n                      <jats:italic>,<\/jats:italic>\n                      \u2265\u200925 pack\u2010years was associated with worse PFS and OS overall and among radiotherapy patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Smoking impacts outcomes in HPV\u2009+\u2009OPC regardless of treatment modality. Treatment\u2010specific differences in prior randomized studies may reflect underlying differences in patient characteristics. \u2265\u200925 pack\u2010years was associated with worse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70298","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:01:17Z","timestamp":1777878077000},"page":"2821-2829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Smoking on Treatment Outcomes in Patients With Human Papillomavirus\u2010Related Oropharyngeal Cancer"],"prefix":"10.1002","volume":"48","author":[{"given":"Michelle M.","family":"Kwan","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latifa A.","family":"Bazzi","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Informatics, Department of Preventive Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9301-6295","authenticated-orcid":false,"given":"Zequn","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Informatics, Department of Preventive Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayton","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-463X","authenticated-orcid":false,"given":"Asher","family":"Park","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois 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University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Akthar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen H.","family":"Lorch","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Northwestern University  Chicago Illinois 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