{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:49:40Z","timestamp":1791982180402,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005242","name":"Universit\u00e9 de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We compared treatment delays, costs, and management impact between oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing in\u2010office versus general anesthesia panendoscopy\u2010guided biopsies in two large tertiary centers in a public healthcare system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All OPSCC patients included were treated between 2010 and 2024 with either curative radiation alone or chemoradiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographic and tumor characteristics were comparable, except for smaller tumors in the panendoscopy group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) compared to the in\u2010office group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) (mean size; 29.4\u2009mm vs. 36.6\u2009mm, respectively; difference \u22127.2\u2009mm [95% CI, \u221211.3 to \u22123.1]). The panendoscopy group experienced substantially longer treatment initiation delays (mean days; 70.1\u2009days vs. 44.5\u2009days; difference 25.7\u2009days [95% CI 13.0 to 38.2]). No additional synchronous tumors were detected through panendoscopy. Panendoscopy incurred a mean additional cost of 2025CAD $3886.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Panendoscopy for OPSCC prolongs treatment initiation, incurs additional expenses, and provides no incremental synchronous tumor detection. When clinically feasible, in\u2010office biopsies should be preferred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70300","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:16:03Z","timestamp":1777428963000},"page":"2792-2799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of In\u2010Office and General Anesthesia Biopsies for Oropharyngeal Squamous Cell Carcinoma in a Public Healthcare System"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3575-1076","authenticated-orcid":false,"given":"Samuel","family":"Bellavance","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-7428","authenticated-orcid":false,"given":"Michel","family":"Khoury","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Colivas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Primiani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Dayan","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bissada","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareck","family":"Ayad","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Tabet","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Guertin","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tabet","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad169"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.1936"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.2414"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.2716"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/19160216251316215"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25007"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.02.010"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/ajo.2020.02.01"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.2553"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418793987"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13897"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103349"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27016"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:21:24Z","timestamp":1791980484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/hed.70300"],"URL":"https:\/\/doi.org\/10.1002\/hed.70300","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}