{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:49:20Z","timestamp":1791982160630,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France between 2012 and 2021 (excluding squamous cell carcinomas and adenoid cystic carcinomas). Data were extracted from the REFCOR (French Network of Expertise on Rare Head and Neck Cancers) and Onco\u2010Occitanie databases, enabling standardized case collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main histological subtypes were intestinal\u2010type adenocarcinomas (42.2%), undifferentiated sinonasal carcinomas (19.3%), and olfactory neuroblastomas (14.5%). The predominantly male (85.5%) cohort, with a median age of 60\u2009years at diagnosis, mainly received first\u2010line platinum\u2010based doublet chemotherapy (platinum\u2010etoposide, platinum\u20105FU). Regardless of histologies and chemotherapy protocols, median overall survival was 13.6\u2009months [10.8; 20.3], with median progression\u2010free survival of 5.3\u2009months [4.4; 6.1]. Complete and partial response rates were 8.3% and 30.6%, respectively, with overall disease control in 73.6% of cases. For adenocarcinomas, platinum\u20105FU and platinum\u2010taxane regimens were preferred. For sinonasal undifferentiated carcinomas, olfactory neuroblastomas, and neuroendocrine carcinomas, platinum\u2010etoposide was most frequently used. Targeted therapies and immunotherapy were rarely used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Improving prognosis requires new strategies, including genomic sequencing and enrollment in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70303","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:01:08Z","timestamp":1777611668000},"page":"2810-2820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4027-8312","authenticated-orcid":false,"given":"Marie","family":"Degrange","sequence":"first","affiliation":[{"name":"Department of Oncology Pau Hospital Center  Pau France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Morisseau","sequence":"additional","affiliation":[{"name":"Biostatistics &amp; Health Data Science Unit Oncopole Claudius Regaud\u2014IUCT\u2010O  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery, CHU La Conception Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Reverdy","sequence":"additional","affiliation":[{"name":"CCU\u2010AH Medical Oncology, Lyon\u2010Sud Hospital Hospices Civils de Lyon  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Morini\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery CHU Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaury","family":"Daste","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Saint\u2010Andr\u00e9 Hospital CHU Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-5687","authenticated-orcid":false,"given":"Maxime","family":"Humbert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery CHU Caen Normandie  Caen France"},{"name":"INSERM U1086 ANTICIPE University of Caen Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Viala","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Corbaux","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer and Hematology Institute CHU Saint\u2010\u00c9tienne  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Darbas","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology CHU Limoges (H\u00f4pital Dupuytren)  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois\u2010R\u00e9gis","family":"Ferrand","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Gustave Roussy Cancer Campus  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Favier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery CHU Montpellier  Montpellier 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