{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:50:12Z","timestamp":1791625812200,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The influence of chronological age on survival after transoral laser microsurgery (TOLMS) for laryngeal squamous cell carcinoma (LSCC) remains unclear, largely because most studies rely on arbitrary age cutoffs and do not account for competing non\u2010cancer mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 676 patients with pT1\u20133 LSCC treated with primary TOLMS (2000\u20132025). Age was modeled per 10\u2010year increase. Overall survival (OS) and disease\u2010specific survival (DSS) were evaluated using Cox, cause\u2010specific Cox, and Fine\u2013Gray competing\u2010risk models. Cumulative incidence of death of disease (DOD) and death from other causes (DOC) were estimated with the Aalen\u2013Johansen method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 68\u2009months, 95 patients died from non\u2010cancer causes and 43 from LSCC. Age strongly predicted OS (HR\u2009=\u20091.90 per decade) but showed only a weak association with DSS and was not significant in Fine\u2013Gray analysis (sHR\u2009=\u20091.26). The pT category and margin status were the dominant predictors of DOD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Age does not meaningfully influence cancer\u2010specific mortality after TOLMS. Apparent age\u2010related differences in survival largely reflect competing non\u2010cancer deaths, supporting treatment decisions based on tumor biology rather than chronological age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70321","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:35:53Z","timestamp":1779161753000},"page":"3064-3071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age Does Not Influence Cancer Mortality After Transoral Laser Microsurgery for Glottic Cancer: A Competing\u2010Risks Analysis of 676 Patients"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-1475","authenticated-orcid":false,"given":"Francesco","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano Filippo","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-4909","authenticated-orcid":false,"given":"Francesco","family":"Bandi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Moglio","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ruju","sequence":"additional","affiliation":[{"name":"Division of Radiology European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohssen","family":"Ansarin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"National Cancer Institute \u201cCancer Stat Facts: Laryngeal Cancer \u201daccessed November 27 2025 https:\/\/seer.cancer.gov\/statfacts\/html\/laryn.html."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000902"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690\u2010024\u201001333\u20101"},{"issue":"4","key":"e_1_2_11_5_1","article-title":"Laser Surgery of Early Glottic Cancer in Elderly","volume":"30","author":"Ansarin M.","year":"2010","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106088"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25616"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29738"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010007\u20100279\u2010z"},{"key":"e_1_2_11_11_1","unstructured":"World Health Organization \u201cAgeing and Health 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