{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:24:19Z","timestamp":1791581059436,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative radiotherapy is the standard treatment for locally advanced oral squamous cell carcinoma (OSCC); however, the indication for neck irradiation (NI) in pN0 patients remains debatable. We evaluated whether the omission of NI compromises outcomes in pT3\u2013T4 pN0 patients treated with adequate neck dissection (ND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010institution study included patients with pT3\u2013T4pN0 OSCC who underwent primary surgery, exhaustive ND (\u2265\u200918 lymph nodes), and postoperative radiotherapy limited to the tumor bed. Overall survival (OS), disease\u2010free survival (DFS), and regional control were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010seven patients were included in the study. After a median follow\u2010up of 51 months, only three nodal recurrences occurred, all associated with local tumor relapse. No isolated neck failures were observed. The regional control rate was 96% and the 5\u2010year OS and DFS rates were 77.6% and 79.2%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In selected pT3\u2013T4 pN0 OSCC patients undergoing high\u2010quality ND, omission of postoperative NI does not compromise oncologic outcomes. This strategy allows for a meaningful reduction in irradiation volumes and potentially treatment\u2010related morbidity, supporting de\u2010escalation of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70325","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:02:05Z","timestamp":1781589725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma"],"prefix":"10.1002","author":[{"given":"Mathilde","family":"Miralli\u00e9","sequence":"first","affiliation":[{"name":"Department of Surgery University Cancer Institute of Toulouse Oncopole, Toulouse University Hospital (CHU)  Toulouse France"},{"name":"Department of Ear, Nose &amp; Throat Surgery Toulouse University Hospital \u2013 Larrey Hospital  Toulouse 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