{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:50:12Z","timestamp":1791625812191,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The benefit of consolidation programmed cell death protein 1 (PD\u20101) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with stages II\u2013IVB NPC were randomized (2:1) to pembrolizumab 200\u2009mg or placebo every 3\u2009weeks for up to 17\u2009cycles after chemoradiotherapy. The primary endpoint was 3\u2010year progression\u2010free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010three patients were randomized (pembrolizumab,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934; placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919). The 3\u2010year PFS rates were 56.5% and 57.8% in the pembrolizumab and placebo arms, respectively (one\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.142; stratified HR, 0.408). Grade 3 or higher adverse events occurred only in the pembrolizumab arm (8.8%). In an exploratory analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940), high intratumoral TIL density was associated with reduced recurrence in the pembrolizumab arm (OR, 0.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) but not the placebo arm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Consolidation pembrolizumab did not improve PFS in unselected locally advanced NPC. Exploratory immune profiling suggested a predictive signal warranting prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70329","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:15:22Z","timestamp":1779419722000},"page":"3103-3112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomized Phase\n                    <scp>II<\/scp>\n                    Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma:\n                    <scp>KCSG HN19<\/scp>\n                    \u201009,\n                    <scp>CONPELAN<\/scp>\n                    Study"],"prefix":"10.1002","volume":"48","author":[{"given":"Sang Hoon","family":"Chun","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Bucheon St. Mary's Hospital, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1201-3194","authenticated-orcid":false,"given":"Seyoung","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine Gil Medical Center, Gachon University College of Medicine  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keon\u2010Uk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keimyung University Dongsan Hospital  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Cheol","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Soonchunhyang University Cheonan Hospital  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Ajou University School of Medicine  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak","family":"Yun","sequence":"additional","affiliation":[{"name":"Rare Cancers Clinic Center for Specific Organs Cancer, National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University Gospel Hospital  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungeun","family":"Lee","sequence":"additional","affiliation":[{"name":"Lunit  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ho","family":"Ahn","sequence":"additional","affiliation":[{"name":"Lunit  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-4247","authenticated-orcid":false,"given":"Bhumsuk","family":"Keam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Cancer Research Institute Seoul National University  Seoul Republic of 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