{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:50:10Z","timestamp":1791625810024,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of virtual surgical planning (VSP) in mandibular osteoradionecrosis (ORN) surgery remains uncertain due to the challenges posed by irradiated tissues<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A consecutive series of patients with mandibular ORN undergoing resection and reconstruction with vascularized hard\u2010tissue free flaps between 1996 and 2004 was included. VSP was analyzed as a predictor variable for ORN recurrence, fixation plate removal, and malocclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 120 patients with mandibular ORN, 49 patients underwent VSP\u2010guided resection and reconstruction. Multivariable Cox proportional hazards regression demonstrated a hazard ratio of 0.544 (95% CI: 0.098\u20133.010,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.485) for ORN recurrence and 0.349 (95% CI: 0.145\u20130.841,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.019) for plate removal. VSP was significantly associated with reduced malocclusion in 2 out of 30 dentate patients, compared to 10 out of 29 dentate patients in the non\u2010VSP group (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VSP appears to be safe for ORN surgery with reduced rates of postoperative complications of plate removal and malocclusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70335","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:46:07Z","timestamp":1779968767000},"page":"3142-3151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Virtual Surgical Planning for Reconstruction of Mandibular Osteoradionecrosis: A Comparative Study on Its Safety and Outcomes"],"prefix":"10.1002","volume":"48","author":[{"given":"Timothy Ping\u2010Juei","family":"Liu","sequence":"first","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Edward","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-6038","authenticated-orcid":false,"given":"Andrew","family":"Schache","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Health Data Science, Institute of Population Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taran","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Stonier","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazilet","family":"Bekiroglu","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owais","family":"Khattak","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Broderick","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Fleming","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-4042","authenticated-orcid":false,"given":"Richard","family":"Shaw","sequence":"additional","affiliation":[{"name":"Liverpool Head &amp; Neck Centre Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.11.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2024.04.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24505"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44276-024-00089-z"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"E165","article-title":"Trends in Chemoradiation Use in Elderly Patients With Head and Neck Cancer: Changing Treatment Patterns With Cetuximab","volume":"38","author":"Baxi S. 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