{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:25:34Z","timestamp":1783164334568,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370959"],"award-info":[{"award-number":["82370959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) is widely used to treat patients with malignant and nonmalignant hematologic disorders. The development of secondary malignancies is recognized, especially secondary oral squamous cell carcinoma (OSCC). This study aimed to evaluate and summarize the risk factors for secondary OSCC after allo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The search was conducted in 3 electronic databases for studies published up to May 2025. The quality of the identified studies was evaluated using the Newcastle\u2010Ottawa Quality Assessment Scale for nonrandomized studies. The results were presented as risk ratios (RRs) with corresponding 95% confidence intervals (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 15\u2009924 patients from 16 studies were included in the systematic review. The results show that, among many factors involved in HSCT, chronic graft\u2010versus\u2010host disease (cGVHD; RR\u2009=\u20094.01, 95% CI\u2009=\u20091.91\u20138.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002), malignant primary diagnosis (RR\u2009=\u20090.40, 95% CI\u2009=\u20090.19\u20130.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and intensity of conditioning myeloablative therapy (RR\u2009=\u20090.41, CI\u2009=\u20090.17\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) were found to be risk factors for secondary OSCC after allo\u2010HSCT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with cGVHD, with a primary diagnosis of malignant disease, or myeloablative intensity of conditioning are more likely to develop secondary OSCC. Our analysis of the literature shows patients after allo\u2010HSCT that required close follow\u2010up, especially examining oral mucosa regularly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70346","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:35:11Z","timestamp":1781328911000},"page":"2238-2249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review and Meta\u2010Analysis of Risk Factors for Secondary Oral Squamous Cell Carcinoma After Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1002","volume":"48","author":[{"given":"Jiaqi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine, College of Stomatology Guangxi Medical University  Nanning Guangxi China"},{"name":"Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Disease  Nanning 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 Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-0757","authenticated-orcid":false,"given":"Renchuan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine, College of Stomatology Guangxi Medical University  Nanning Guangxi China"},{"name":"Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Disease  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01227-8"},{"key":"e_1_2_10_3_1","unstructured":"Center for International Blood & Marrow Transplant Research \u201cAnnual Report 2022 \u201d2022 accessed July 2024 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