{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:47:47Z","timestamp":1782791267691,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in previously untreated primary mucosal head and neck cancer (HNC) patients unfit for conventional radiation therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of previously unirradiated primary SCC mucosal HNC patients treated with SBRT from 2011 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HN SBRT was prescribed to 74 patients (median age: 81\u2009years [52\u201397]; 85% ECOG 2\u20133) with 77 primary tumors (62% oral cavity; 64% T3\u20104 disease). A five\u2010fraction prescription ranging from 35 to 50\u2009Gy (95% received \u2265\u200940\u2009Gy, 59.7% received \u2265\u200945\u2009Gy) was delivered twice weekly, with the majority (81%) completing treatment within 14\u2009days and all patients completing treatment. Symptomatic relief was achieved by 84%, including 27.3% with complete symptomatic response. With a median follow\u2010up of 7.3\u2009months, 1\u2010year outcomes were 81% local control, 16% regional recurrence rate, and 12% distant metastasis rate. Median progression\u2010free and overall survival were 6.4 and 8\u2009months, respectively. Acute Grade 3+ toxicity occurred in 36%, primarily mucositis (30%). Late Grade \u2265\u20093 toxicity was observed in 10% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097), including osteoradionecrosis in 5 patients, with residual or concurrent disease present in 5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094). PTV &gt;\u2009159\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      was significantly correlated with late grade \u2265\u20093 toxicity (OR\u2009=\u200915.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High\u2010dose SBRT may deliver high rates of local control and palliation for primary mucosal HNC patients unfit for conventional radiation, but prospective, comparative, high\u2010quality data are needed. A randomized trial (NCT06641791) comparing SBRT to conventional palliative RT in the elderly unfit HNC patient is underway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70360","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:42:11Z","timestamp":1782790931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stereotactic Body Radiotherapy (\n                    <scp>SBRT<\/scp>\n                    ) of Previously Unirradiated Mucosal Head and Neck Squamous Cell Carcinoma (\n                    <scp>SCC<\/scp>\n                    )"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2989-3052","authenticated-orcid":false,"given":"Mohammed","family":"Aldohan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Comprehensive Cancer Center King Fahad Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-3535","authenticated-orcid":false,"given":"Irene","family":"Karam","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir H.","family":"Safavi","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Chin","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Gooanratne","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madette","family":"Galapin","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Eskander","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Higgins","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Enepekides","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Poon","sequence":"additional","affiliation":[{"name":"Odette Cancer Centre \u2010 Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.04.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(06)69121\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2018.03.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8983"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1064"},{"key":"e_1_2_8_7_1","unstructured":"Canadian Cancer Statistics Advisory Committee \u201cCanadian Cancer Statistics 2022 \u201dCanadian Cancer Society 2022 https:\/\/cancer.ca\/en\/research\/cancer\u2010statistics."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030472"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.lungcan.2016.11.009","article-title":"Trends in Stereotactic Body Radiation Therapy for Stage I Small Cell Lung Cancer","volume":"103","author":"Stahl J. M.","year":"2017","journal-title":"Lung Cancer"},{"issue":"2","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.21037\/apm.2016.03.05","article-title":"Stereotactic Radiosurgery\/Stereotactic Body Radiation Therapy\u2010Reflection on the Last Decade's Achievements and Future Directions","volume":"5","author":"Knisely J.","year":"2016","journal-title":"Annals of Palliative Medicine"},{"issue":"5","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.ijrobp.2020.12.001","article-title":"Is SABR Cost\u2010Effective in Oligometastatic Cancer? An Economic Analysis of the SABR\u2010COMET Randomized Trial","volume":"109","author":"Qu X. M.","year":"2021","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"7","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2217\/fon-2016-0403","article-title":"Survey of Current Practices From the International Stereotactic Body Radiotherapy Consortium (ISBRTC) for Head and Neck Cancers","volume":"13","author":"Karam I.","year":"2017","journal-title":"Future Oncology"},{"issue":"1","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.adro.2020.11.013","article-title":"Stereotactic Radiation Therapy for De Novo Head and Neck Cancers: A Systematic Review and Meta\u2010Analysis","volume":"6","author":"Malik N. H.","year":"2021","journal-title":"Advances in Radiation Oncology"},{"issue":"11","key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1002\/hed.26820","article-title":"Stereotactic Body Ablative Radiotherapy for Reirradiation of Small Volume Head and Neck Cancers Is Associated With Prolonged Survival: Large, Single\u2010Institution, Modern Cohort Study","volume":"43","author":"Diao K.","year":"2021","journal-title":"Head & Neck"},{"key":"e_1_2_8_15_1","volume-title":"AJCC Cancer Staging Manual","author":"AJCC","year":"2018"},{"key":"e_1_2_8_16_1","volume-title":"Common Terminology Criteria for Adverse Events Verion 5.0","author":"U.S. Department of Health and Human Services","year":"2017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New Response Evaluation Criteria in Solid Tumours: Revised RECIST Guideline (Version 1.1)","volume":"45","author":"Eisenhauer E. A.","year":"2009","journal-title":"European Journal of Cancer"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.10.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.07.011"},{"key":"e_1_2_8_20_1","unstructured":"Government of Canada \u201cA Portrait of Canada's Growing Population Aged 85 and Older From the 2021 Census \u201d2022 https:\/\/www12.statcan.gc.ca\/census\u2010recensement\/2021\/as\u2010sa\/98\u2010200\u2010X\/2021004\/98\u2010200\u2010X2021004\u2010eng.cfm."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.02.022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26138"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26342"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00196\u20100"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110611"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:42:20Z","timestamp":1782790940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":24,"alternative-id":["10.1002\/hed.70360"],"URL":"https:\/\/doi.org\/10.1002\/hed.70360","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2026-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70360"}}