{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:47:12Z","timestamp":1782452832676,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The primary goal of the study is to assess bleeding complications and evaluate ketorolac for its safety in cancer patients undergoing head and neck free\u2010flap surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two cohorts of head and neck cancer patients undergoing free\u2010flap surgery were identified using ICD\u201010 and CPT codes. Cohort 1 received ketorolac within 5\u2009days of surgery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092280); Cohort 2 did not receive ketorolac within 5\u2009days of surgery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092280). Postoperative hemorrhage occurrence and secondary outcomes were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ketorolac was not associated with increased risk of postoperative hemorrhage (RR: 0.825,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), flap revisions (RR: 0.767,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), blood vessel repair (RR: 0.528,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), AKI (RR: 0.664,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and G\u2010tube placement (RR: 0.884,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective cohort, postoperative ketorolac was not associated with increased complications within the 30\u2010day period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70376","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:06:53Z","timestamp":1782450413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ketorolac Use After Head and Neck Free Tissue Transfer Is Not Associated With Increased Flap Complications"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8584-2664","authenticated-orcid":false,"given":"Joseph K.","family":"Byorth","sequence":"first","affiliation":[{"name":"Creighton University School of Medicine  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-7016","authenticated-orcid":false,"given":"Silvia M.","family":"Soule","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brayden J.","family":"Seliger","sequence":"additional","affiliation":[{"name":"University of Toledo College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Bavier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Drejet","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke O.","family":"Buchmann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary C.","family":"McCrary","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002069"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414526849"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211032910"},{"issue":"6","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/PRS.0b013e31824ec33f","article-title":"The Effects of Ketorolac on Microvascular Thrombosis in Lower Extremity Reconstruction","volume":"129","author":"Lee K. T.","year":"2012","journal-title":"Plastic and Reconstructive Surgery"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00238\u2010018\u20101417\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2021.01.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004294"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000217"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010200102000\u201000009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438459.60474.b5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101263070"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20758"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002369"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(87)90498\u20100"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:06:54Z","timestamp":1782450414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":14,"alternative-id":["10.1002\/hed.70376"],"URL":"https:\/\/doi.org\/10.1002\/hed.70376","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70376"}}