{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:59:56Z","timestamp":1785207596797,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multi\u2010institutional case\u2010series (1995\u20132015) of patients who underwent skull base surgery for anterior face\/scalp cSCC. Kaplan\u2013Meier and Cox regression analyses assessed disease\u2010free (DFS), disease\u2010specific (DSS), and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 112 patients, most had T4 (86.6%) and recurrent (71.4%) disease. Clear margins were achieved in 32.1%; 40.2% were involved. Five\u2010year DFS, DSS, and OS were 46.9%, 68.4%, and 52.3%, respectively. Intracranial extension independently predicted worse OS (HR:6.54 [95% CI:2.61,16.38]) and DSS (HR:12.39 [95% CI:2.72,56.45]). Involved margins predicted recurrence on univariable analysis. Adjuvant therapy, predominantly post\u2010operative radiotherapy, improved OS (HR: 0.54 [95% CI: 0.30,0.97]). Complications occurred in 38.4%, with 4.5% perioperative mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Advanced anterior skull base cSCC carries substantial morbidity and modest survival. These data provide a benchmark against which immunotherapy\u2010based strategies should be evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70412","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:27:20Z","timestamp":1785205640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case\u2010Series"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-3946","authenticated-orcid":false,"given":"Michael J. C.","family":"Schachtel","sequence":"first","affiliation":[{"name":"Queensland Skull Base Unit and Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-3773","authenticated-orcid":false,"given":"Benedict J.","family":"Panizza","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit and Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Bowman","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit and Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5051-1750","authenticated-orcid":false,"given":"Catherine","family":"Barnett","sequence":"additional","affiliation":[{"name":"Queensland Skull Base Unit and Department of Otolaryngology Head and Neck Surgery, Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-2888","authenticated-orcid":false,"given":"Cristina","family":"Valero","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York 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