{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:23:02Z","timestamp":1787836982884,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fanconi anemia (FA) is associated with markedly increased risk for early\u2010onset oral squamous cell carcinoma (OSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report an aggressive mandibular squamous cell carcinoma in a 26\u2010year\u2010old non\u2010transplanted woman with FA initially interpreted as localized periodontal disease adjacent to a tongue leukoplakia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Initial examination demonstrated mild gingival inflammation and localized alveolar bone loss involving the right mandibular molars. Forty\u2010five days later, the patient returned with facial asymmetry, severe bone destruction, and grade III tooth mobility. Cone beam computed tomography revealed extensive mandibular osteolysis, and biopsy confirmed squamous cell carcinoma with extensive intraosseous involvement. Despite surgical treatment, the patient died 3 months later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights the potential limitations of surveillance strategies focused predominantly on visible mucosal lesions and reinforces that rapidly progressive periodontal\u2010like destruction in patients with FA should raise immediate suspicion for malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70446","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:05:09Z","timestamp":1787835909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive Mandibular Squamous Cell Carcinoma Mimicking Periodontal Disease in a Non\u2010Transplanted Patient With Fanconi Anemia"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-7544","authenticated-orcid":false,"given":"Cassius Carvalho","family":"Torres\u2010Pereira","sequence":"first","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 (UFPR)  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Grein","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 (UFPR)  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Aparecida Alberton","family":"Nuernberg","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 (UFPR)  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-0782","authenticated-orcid":false,"given":"Juliana Lucena","family":"Schussel","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 (UFPR)  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-6870","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Amen\u00e1bar C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1 (UFPR)  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.02.013"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32435"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106699"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HTCT.2026.106462"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13030"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010023\u201000834\u20109"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107BOR\u20102023.VOL37.0012"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/SCD.70035"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2013.09.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516678169"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2020.07.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25417"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.009"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12151"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.06.012"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.jomfp_280_21"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26622"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30370"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12899"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5327\/2525\u20105711.378"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNCY.22249;WGROUP:STRING:PUBLICATION"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5571649"}],"container-title":["Head &amp; 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