{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:17:20Z","timestamp":1787905040759,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>DEK::AFF2 fusion\u2010associated carcinoma is a recently recognized subtype of nonkeratinizing squamous cell carcinoma that may be underdiagnosed due to overlap with benign sinonasal lesions and reliance on molecular confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 39\u2010year\u2010old woman at 29\u2009weeks' gestation presented with progressive swelling of the left nasal ala. She had a prior resection of DEK::AFF2 carcinoma and was lost to follow\u2010up. MRI demonstrated a 2.9\u2010cm recurrent mass, and incisional biopsy confirmed recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Given the historically described low\u2010 to intermediate\u2010grade behavior of this tumor, the multidisciplinary tumor board recommended deferring surgery until after term delivery. However, the lesion demonstrated rapid progression over 4\u2009weeks, enlarging to 4.5\u2009cm. Following repeat tumor board discussion, labor was induced at 36\u2009weeks, followed by medial maxillectomy, neck dissection, and free flap reconstruction. Final pathology revealed pT4aN1 disease. The patient completed adjuvant radiation therapy and remains disease\u2010free at 8\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case highlights potential aggressive behavior in DEK::AFF2 carcinoma and possible pregnancy\u2010associated tumor acceleration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70451","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:26:47Z","timestamp":1787902007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Rapidly Progressive\n                    <scp>DEK<\/scp>\n                    ::\n                    <scp>AFF2<\/scp>\n                    Fusion\u2010Associated Papillary Squamous Cell Carcinoma in Pregnancy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-4696","authenticated-orcid":false,"given":"Muhammad","family":"El Shatanofy","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Pena","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Aaron","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-689X","authenticated-orcid":false,"given":"Ammanuel K.","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-2748","authenticated-orcid":false,"given":"Jaylou M.","family":"Velez Torres","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-4076","authenticated-orcid":false,"given":"Larissa","family":"Sweeny","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3417-2762","authenticated-orcid":false,"given":"Erin R.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.path.2024.07.008","article-title":"DEK::AFF2 Carcinoma of the Sinonasal Tract and Skull Base: A Comprehensive Review","volume":"17","author":"Rivera J. P.","year":"2024","journal-title":"Surgical Pathology Clinics"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/PAS.0000000000001596","article-title":"Nonkeratinizing Squamous Cell Carcinoma of the Sinonasal Tract With DEK\u2010AFF2: Further Solidifying an Emerging Entity","volume":"45","author":"Bishop J. A.","year":"2021","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1097\/PAS.0000000000002281","article-title":"Sinonasal Squamous Cell Carcinoma With DEK::AFF2 Rearrangement: An Aggressive Cancer With Bland Morphology","volume":"48","author":"Trinquet A.","year":"2024","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41591-019-0434-2","article-title":"Immunogenic Neoantigens Derived From Gene Fusions Stimulate T Cell Responses","volume":"25","author":"Yang W.","year":"2019","journal-title":"Nature Medicine"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001117\u20104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046985"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103897"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010025\u201001799\u20107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969241301061"},{"key":"e_1_2_8_12_1","first-page":"155","article-title":"Molecular Identification, Expression and Prognostic Role of Estrogen\u2010 and Progesterone Receptors in Head and Neck Cancer","volume":"30","author":"Lukits J.","year":"2007","journal-title":"International Journal of Oncology"},{"issue":"10","key":"e_1_2_8_13_1","first-page":"2749","article-title":"Placental Growth Factor Is a Survival Factor for Tumor Endothelial Cells and Macrophages","volume":"62","author":"Adini A.","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2524"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.18.1472"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201025\u201002115"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmf2.70221"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:26:49Z","timestamp":1787902009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":16,"alternative-id":["10.1002\/hed.70451"],"URL":"https:\/\/doi.org\/10.1002\/hed.70451","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"2026-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70451"}}