{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:07:57Z","timestamp":1788746877311,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence for adjuvant immune checkpoint inhibitor (ICI) therapy after curative\u2010intent resection of sinonasal mucosal melanoma (SNMM) is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 11 patients with resectable\u00a0N0M0 SNMM who underwent curative\u2010intent endoscopic resection followed by adjuvant ICI. Outcomes and immune\u2010related adverse events (irAEs) were summarized descriptively, and univariable Cox proportional hazards regression was performed as an exploratory analysis to explore potential risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 1\u2010 and 3\u2010year overall survival rates were 100.0% and 90.0%; recurrence\u2010free survival rates were 45.5% and 0%. Any\u2010grade and grade \u2265\u20093 irAEs occurred in 8 of 11 patients (72.7%) and 3 patients (27.3%). T4a disease was associated with shorter recurrence\u2010free survival than T3 disease (hazard ratio, 13.96; 95% confidence interval, 1.24\u2013157.50;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recurrence was frequent and early, whereas overall survival remained preserved. Although efficacy cannot be inferred without a comparator, these data support multicenter evaluation of treatment sequencing and risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70454","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:41:12Z","timestamp":1788745272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Curative\u2010Intent Endoscopic Resection Combined With Adjuvant Immune Checkpoint Inhibition for Resectable Sinonasal Mucosal Melanoma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-1450","authenticated-orcid":false,"given":"Teru","family":"Ebihara","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2209-5722","authenticated-orcid":false,"given":"Soichiro","family":"Fukuzato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4337-4745","authenticated-orcid":false,"given":"Kazuhiro","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-3316","authenticated-orcid":false,"given":"Yuma","family":"Waki","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-8930","authenticated-orcid":false,"given":"Yoshimasa","family":"Nobeyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midoriko","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Otori","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000457937","article-title":"Sinonasal Malignant Melanoma","volume":"84","author":"Lund V. J.","year":"2020","journal-title":"Advances in Oto\u2010Rhino\u2010Laryngology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/diagnostics15040496","article-title":"Primary Sinonasal Mucosal Melanoma: A Narrative Review","volume":"15","author":"Todorovic N.","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.6004\/jnccn.2025.0007","article-title":"NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2025","volume":"23","author":"Colevas A. D.","year":"2025","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S1470-2045(20)30494-0","article-title":"Adjuvant Nivolumab Versus Ipilimumab in Resected Stage IIIB\u2010C and Stage IV Melanoma (CheckMate 238): 4\u2010Year Results From a Multicentre, Double\u2010Blind, Randomised, Controlled Phase 3 Trial","volume":"21","author":"Ascierto P. A.","year":"2020","journal-title":"Lancet Oncology"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101750178"},{"key":"e_1_2_13_7_1","volume-title":"AJCC Cancer Staging Manual","author":"Amin M. B.","year":"2018"},{"key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/cncr.24976","article-title":"Mucosal Melanoma of the Nose and Paranasal Sinuses: A Contemporary Experience From the M.D. Anderson Cancer Center","volume":"116","author":"Moreno M. A.","year":"2010","journal-title":"Cancer"},{"key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/alr.21558","article-title":"Treatment Outcomes of Sinonasal Malignant Melanoma: A Korean Multicenter Study","volume":"5","author":"Won T. B.","year":"2015","journal-title":"International Forum of Allergy & Rhinology"},{"key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s10147-023-02368-0","article-title":"Treatment Outcomes of Patients With Sinonasal Mucosal Melanoma: The Role of Endoscopic Resection and Postoperative Radiotherapy","volume":"28","author":"Tsushima N.","year":"2023","journal-title":"International Journal of Clinical Oncology"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.anorl.2016.05.008","article-title":"Prognostic Value of Two Tumour Staging Classifications in Patients With Sinonasal Mucosal Melanoma","volume":"133","author":"Houette A.","year":"2016","journal-title":"European Annals of Otorhinolaryngology, Head and Neck Diseases"},{"key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/hed.23298","article-title":"Sinonasal Mucosal Melanomas: The Prognostic Value of Tumor Classifications","volume":"36","author":"Michel J.","year":"2014","journal-title":"Head & Neck"},{"key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1245\/s10434-018-6465-y","article-title":"Patterns of Treatment Failure in Patients With Sinonasal Mucosal Melanoma","volume":"25","author":"Amit M.","year":"2018","journal-title":"Annals of Surgical Oncology"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/lary.28065","article-title":"Nodal and Distant Metastases in Sinonasal Mucosal Melanoma: A Population\u2010Based Analysis","volume":"130","author":"Low C. M.","year":"2020","journal-title":"Laryngoscope"},{"key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1245\/s10434-011-1685-4","article-title":"Predictors of Survival in Mucosal Melanoma of the Head and Neck","volume":"18","author":"Jethanamest D.","year":"2011","journal-title":"Annals of Surgical Oncology"},{"key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hed.10019","article-title":"Primary Mucosal Malignant Melanoma of the Head and Neck","volume":"24","author":"Patel S. G.","year":"2002","journal-title":"Head & Neck"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:41:14Z","timestamp":1788745274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":15,"alternative-id":["10.1002\/hed.70454"],"URL":"https:\/\/doi.org\/10.1002\/hed.70454","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"2026-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70454"}}