{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:19:13Z","timestamp":1788142753081,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of human papillomavirus\u2010associated (HPV) oropharyngeal squamous cell carcinoma (OPSCC) is rising, making accurate detection of synchronous primary tumors essential for staging and treatment planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi\u2010institutional retrospective cohort study (2019\u20132026) included adult participants across three academic tertiary centers who underwent PET\/CT and subsequent biopsy or surgical resection with histopathological confirmation of p16\u2010positive disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 306 patients meeting inclusion criteria, PET\/CT identified 15 suspicious for synchronous primary tumors; seven (mean age 58.90\u2009\u00b1\u200911.48\u2009years) were pathologically confirmed. PET\/CT demonstrated 77.78% sensitivity, 97.31% specificity, 46.67% positive predictive value (PPV), and 99.31% negative predictive value (NPV). False positives were attributed to physiologic bilateral uptake, reactive lymphoid tissue, or inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>PET\/CT demonstrates excellent NPV for excluding synchronous primary tumors in HPV\u2010positive OPSCC and moderate PPV for identifying them. In settings of multifocal fluorodeoxyglucose uptake, pathologic confirmation is warranted prior to definitive management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70455","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:55:12Z","timestamp":1788141312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    Diagnostic Accuracy for Synchronous Primary\n                    <scp>HPV<\/scp>\n                    \u2010Positive Oropharyngeal Tumors: A Multi\u2010Institutional Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2688-8082","authenticated-orcid":false,"given":"Mei Xing G.","family":"Zuo","sequence":"first","affiliation":[{"name":"Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0474-9273","authenticated-orcid":false,"given":"Varsha","family":"Pudi","sequence":"additional","affiliation":[{"name":"Robert Larner, M.D. College of Medicine at the University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5827-0945","authenticated-orcid":false,"given":"Srikar","family":"Ganapathiraju","sequence":"additional","affiliation":[{"name":"Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6148-6194","authenticated-orcid":false,"given":"Christopher P.","family":"Kruglik","sequence":"additional","affiliation":[{"name":"Robert Larner, M.D. College of Medicine at the University of Vermont  Burlington Vermont USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5662-5901","authenticated-orcid":false,"given":"Kyra S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihan","family":"Ercanli","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-6797","authenticated-orcid":false,"given":"Joseph A.","family":"Paydarfar","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Audiology and Maxillofacial Surgery Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-7739","authenticated-orcid":false,"given":"Mirabelle B.","family":"Sajisevi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of Vermont Medical Center  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Gildener\u2010Leapman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa T.","family":"Galati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.32481\/djph.2023.04.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28238"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092651"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244\u2010014\u20100349\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.22038\/aojnmb.2024.76461.1536"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"E30","article-title":"Synchronous Bilateral Tonsillar Squamous Cell Carcinoma Related to Human Papillomavirus: Two Case Reports and a Brief Review of the Literature","volume":"95","author":"Rasband\u2010Lindquist A.","year":"2016","journal-title":"Ear, Nose, & Throat Journal"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1615"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104475"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820968800"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2025.1833"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD016160"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30179\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.2556"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:55:13Z","timestamp":1788141313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":14,"alternative-id":["10.1002\/hed.70455"],"URL":"https:\/\/doi.org\/10.1002\/hed.70455","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70455"}}