{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:08:08Z","timestamp":1788761288279,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Head and neck squamous cell carcinoma (HNSCC) arises from premalignant lesions and has a high rate of disease relapse. Novel therapies are needed to treat established tumors and prevent progression of premalignant lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multiple immunocompetent murine models of oral cancer were used to explore the effects of blueberry extract (BE) on tumor control and anti\u2010tumor immune responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BE added to drinking water provided robust tumor growth delay, resulting in frequent tumor rejection when combined with anti\u2010PD\u20101 immunotherapy in one model. Tumor immune profiling, RNA sequencing, and cell depletion studies suggest that BE acts primarily via non\u2010immune, antioxidant mechanisms. When given to mice in the 4\u2010NQO carcinogenesis model, BE showed modest activity as a chemoprevention strategy; in a model mimicking minimal residual disease, BE showed no appreciable benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that BE may have some utility as an adjunct to standard therapies for HNSCC, with limited utility during early tumorigenesis but more efficacy at later stages of tumor progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70466","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:32:52Z","timestamp":1788759172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blueberry Extract Has Anti\u2010Proliferative Activity in Preclinical Models of Head and Neck Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3516-3008","authenticated-orcid":false,"given":"Brendan L. C.","family":"Kinney","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Emory University  Atlanta Georgia USA"},{"name":"Winship Cancer Institute Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-2374","authenticated-orcid":false,"given":"Daniel","family":"Lubin","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute Emory University  Atlanta Georgia USA"},{"name":"Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8240-2112","authenticated-orcid":false,"given":"Vikash","family":"Kansal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Emory University  Atlanta Georgia USA"},{"name":"Winship Cancer Institute Emory University  Atlanta Georgia 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystal M.","family":"Paulos","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute Emory University  Atlanta Georgia USA"},{"name":"Department of Surgery Emory University  Atlanta Georgia USA"},{"name":"Department of Microbiology and Immunology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-1477","authenticated-orcid":false,"given":"Nabil F.","family":"Saba","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute Emory University  Atlanta Georgia USA"},{"name":"Department of Hematology and Oncology Emory University  Atlanta Georgia 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