{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:13:16Z","timestamp":1788757996221,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head & Neck"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Peripheral leakage around a tracheoesophageal puncture (\n TEP<\/jats:styled-content>\n ) voice prosthesis increases patient morbidity. This study describes the use of carboxymethylcellulose (\n CMC<\/jats:styled-content>\n ) gel in managing peripheral leakage.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A single\u2010institution retrospective review was conducted of postlaryngectomy\n TEP<\/jats:styled-content>\n patients who received\n CMC<\/jats:styled-content>\n gel injections for periprosthetic leakage. Data obtained included demographics, comorbidities, and postinjection outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Six male patients (mean age, 58.3\u2009years) underwent 38\n CMC<\/jats:styled-content>\n injections total. Thirty\u2010six (95%) injections resulted in immediate leak resolution. Four patients (67%) received repeat injections for recurrent leakage. One patient on anticoagulation experienced mild postinjection bleeding; no other adverse events were documented. The median leak\u2010free duration was 2.32\u2009months (range, 0.07\u201341.33), with an average duration of 4.32\u2009months. Average follow\u2010up period was 11.08\u2009years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This is the first study reporting the use of\n CMC<\/jats:styled-content>\n gel for\n TEP<\/jats:styled-content>\n tract augmentation. Despite variability in response duration,\n CMC<\/jats:styled-content>\n gel was safe and resulted in immediate leak resolution in almost all cases, highlighting its potential utility in managing peripheral\n TEP<\/jats:styled-content>\n leakage.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.70467","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:05:39Z","timestamp":1788757539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Managing Periprosthetic Leakage After Tracheoesophageal Puncture With Carboxymethylcellulose Gel"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1671-428X","authenticated-orcid":false,"given":"Jin Hua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Weill Cornell Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Weill Cornell Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Harter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Weill Cornell Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kutler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Weill Cornell Medicine New York New York USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery New York\u2010Presbyterian\/Weill Cornell Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22401"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.3422"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13071064"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010014\u20103393\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100145372"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537\u2010200208000\u201000034"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21399"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1145"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537\u2010198812000\u201000014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010004\u20100747\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14052"},{"key":"e_1_2_10_13_1","unstructured":"Merz North America Inc. \u201cProlaryn Gel Injectable Implant Instructions for Use \u201dhttps:\/\/prolaryn.com\/web\/pdfs\/EM01003\u201001.pdf."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25162"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otoeng.2015.12.003"}],"container-title":["Head & Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:05:41Z","timestamp":1788757541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":14,"alternative-id":["10.1002\/hed.70467"],"URL":"https:\/\/doi.org\/10.1002\/hed.70467","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"2026-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70467"}}