{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:03:56Z","timestamp":1789729436435,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The importance of ensuring clear margins following resection for oral squamous cell carcinoma (OSCC) has been well described in the literature, however, accurate intra\u2010operative assessment of tumor margins in these patients remains problematical. Positive margins are known to be associated with a significant reduction in survival and the addition of adjuvant radiotherapy for this group of patients does not change survival, meaning that patients are subjected to the additional co\u2010morbidities of chemo\u2010radiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We describe the use of a novel intra\u2010operative PET\u2010CT scanner (Aura 10, Xeos, Ghent) to evaluate margin status for 18 patients undergoing excision of OSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intra\u2010operative PET\u2010CT showed a high positive predictive value for positive margins but was less accurate in confirming a negative margin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This new technology shows early promise in improving margin resection rates in oral cancer patients but requires a larger sample size or multi\u2010center trial for further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70474","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:16:28Z","timestamp":1789726588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Intraoperative\n                    <scp>PET<\/scp>\n                    \u2010\n                    <scp>CT<\/scp>\n                    in the Assessment of Surgical Margins for Patients With Oral Squamous Cell Carcinoma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8178-338X","authenticated-orcid":false,"given":"Gary M.","family":"Walton","sequence":"first","affiliation":[{"name":"Department of Head &amp; Neck Surgery University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-5371","authenticated-orcid":false,"given":"Oludolapo","family":"Adesanya","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-4897","authenticated-orcid":false,"given":"Lisa","family":"Rowley","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"},{"name":"Institute for Precision Diagnostics &amp; Translational Medicine (IPDTM), University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-8887","authenticated-orcid":false,"given":"Susanna E.","family":"Kallioinen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"},{"name":"The University of Warwick  Warwick UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alica","family":"Torres\u2010Rendon","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospitals, Coventry &amp; Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospitals, Coventry &amp; Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-4087","authenticated-orcid":false,"given":"Reshma","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospitals, Coventry &amp; Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Pickles","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Surgery University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prady","family":"Naredla","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Surgery University Hospitals, Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/ohn.377","article-title":"Trends in Positive Margins in cT3\u2010T4 Oral Cavity Squamous Cell Carcinoma","volume":"169","author":"Prasad K.","year":"2023","journal-title":"Otolaryngology and Head and Neck Surgery"},{"key":"e_1_2_11_3_1","unstructured":"J.Moraton D.Horn M.Oehme et\u00a0al. \u201cVariation of Resection Margins in Oral Cancer in Dependence of Tumour Stage and Subsite\u2014A Retrospective Cohort Study.\u201d"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105499","article-title":"The Impact of Positive Margin on Survival in Oral Cavity Squamous Cell Carcinoma","volume":"122","author":"Patel V.","year":"2021","journal-title":"Oral Oncology"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/1097-0347(200103)23:3<230::AID-HED1023>3.0.CO;2-V","article-title":"Relocating the Site of Frozen Sections? Is There Room for Improvement?","volume":"23","author":"Kerawala C. J.","year":"2001","journal-title":"Head & Neck"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105579","article-title":"Radiotherapy Does not Improve Survival in Patients With Positive Margins. Need to Revise Guidelines?","volume":"123","author":"Kumar A.","year":"2021","journal-title":"Oral Oncology"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"E1803","article-title":"Improving the Rate of Negative Margins After Surgery for Oral Cavity Squamous Cell Carcinoma: A Prospective Randomised Controlled Study","volume":"38","author":"Amit M.","year":"2016","journal-title":"Head & Neck"},{"issue":"2","key":"e_1_2_11_8_1","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to Build a Bridge From a Population\u2010Based to a More \u201cPersonalised\u201d Approach to Cancer Staging","volume":"67","author":"Amin M. B.","year":"2017","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"10","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamaoto.2022.2131","article-title":"Use of Intra\u2010Operative Frozen Section to Assess Final Tumour Margin Status in Patients Undergoing Surgery for Oral Cavity Squamous Cell Carcinoma","volume":"148","author":"Long S. M.","year":"2022","journal-title":"JAMA Otolaryngology. Head & Neck Surgery"},{"issue":"7","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0278-2391(97)90570-X","article-title":"Accuracy of Frozen Sections in Assessing Margins in Oral Cancer Resection","volume":"55","author":"Ord R. A.","year":"1997","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"46","article-title":"Frozen Section Evaluation in Head and Neck Oncosurgery: An Initial Experience in a Tertiary Cancer","volume":"35","author":"Nayanar S. K.","year":"2019","journal-title":"Turkish Journal of Pathology"},{"issue":"1","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijom.2025.08.006","article-title":"Utility of Frozen Section Pathology in Oral Squamous Cell Carcinoma; A Systematic Review and meta\u2010Analysis","volume":"55","author":"Armstrong L. T. D.","year":"2026","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14143416","article-title":"In vivo Imaging Modalities in Head and Neck Cancer Surgical Margin Delineation: A Systematic Review","volume":"14","author":"Young K.","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"59","article-title":"Intra\u2010Operative Use of PET Probe for Localization of FDG Avid Lesions","volume":"9","author":"Molina M. A.","year":"2009","journal-title":"Cancer Imaging"},{"issue":"5","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/00015458.2020.1774163","article-title":"18F\u2010FDG Micro\u2010PET\/CT for Intra\u2010Operative Margin Assessment During Breast\u2010Conserving Surgery","volume":"120","author":"Goker M.","year":"2020","journal-title":"Acta Chirurgica Belgica"},{"issue":"2","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.108821","article-title":"Exploring the Use of the Mobile PET\/CT\u2010Camera for Intraoperative Imaging of Surgical Specimens of the (Para)thyroid and\/or Cervical Lymph Nodes","volume":"50","author":"Vergucht V.","year":"2024","journal-title":"European Journal of Surgical Oncology"},{"issue":"2","key":"e_1_2_11_17_1","article-title":"High Resolution PET\/CT Imaging of Surgical Specimens: Exploring the Use of the Mobile AURA 10 Camera by Surgeons in a General Hospital","volume":"65","author":"Lambert B.","year":"2024","journal-title":"Journal of Nuclear Medicine"},{"issue":"7","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s00259-023-06153-z","article-title":"Direct Co\u2010Registration of [18F]FDG Uptake and Histopathology in Surgically Excised Malignancies of the Head and Neck: A Feasibility Study","volume":"50","author":"Debacker J. M.","year":"2023","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_11_19_1","article-title":"It's PET but Not as We Know It: Radiation Protection Considerations When Using a Novel Specimen PET\u2010CT Scanner During Tumour Resections for Urology and Head and Neck Patients","volume":"13","author":"Rowley L. M.","year":"2026","journal-title":"EJNMMI Physics"},{"key":"e_1_2_11_20_1","unstructured":"\u201cThe Ionising Radiations Regulations (IRR) \u201d(2017)."}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70474","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:16:33Z","timestamp":1789726593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":19,"alternative-id":["10.1002\/hed.70474"],"URL":"https:\/\/doi.org\/10.1002\/hed.70474","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70474"}}