{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:50:30Z","timestamp":1791438630106,"version":"4.3.3"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>TTMV\u2010HPV DNA testing is prognostic during post\u2010treatment surveillance of HPV\u2010associated oropharyngeal squamous cell carcinoma (OPSCC), but the significance of testing before conventional 3\u2010month response assessment remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 332 patients across 8 US sites with biopsy\u2010proven HPV\u2010associated OPSCC who underwent initial definitive treatment and had \u2265\u20091 TTMV\u2010HPV DNA test performed 1 to 89\u2009days after treatment completion. Event\u2010free survival (EFS) was evaluated using a 90\u2010day landmark approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The first TTMV\u2010HPV DNA test obtained 1\u201389\u2009days after treatment was negative in 310 patients (93%), indeterminate in 3 (1%), and positive in 19 (6%). Among 59 patients with repeat testing after an initially negative result, 57 (97%) remained negative and 2 (3%) converted to positive; both patients who converted subsequently developed recurrence. Of 13 patients with an initially positive result and sufficient follow\u2010up for trajectory analysis, 6 (46%) subsequently resolved to negative and none developed recurrence, whereas 7 (54%) remained persistently positive and 6 (86%) developed recurrence. In a 90\u2010day landmark analysis, the last early post\u2010treatment TTMV\u2010HV DNA result was associated with subsequent event\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TTMV\u2010HPV DNA testing during the 1\u201389\u2010day post\u2010treatment interval was associated with subsequent clinical outcomes in HPV\u2010associated OPSCC. Persistent positivity identified patients at increased risk, whereas positive results that resolved were not followed by recurrence in this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70483","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:02:03Z","timestamp":1791435723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of Early Post\u2010Treatment Circulating Tumor Tissue Modified Viral\n                    <scp>HPV DNA<\/scp>\n                    Testing in\n                    <scp>HPV<\/scp>\n                    \u2010Associated Oropharyngeal Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-0910","authenticated-orcid":false,"given":"Scott A.","family":"Roof","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-0395","authenticated-orcid":false,"given":"James","family":"Jabalee","sequence":"additional","affiliation":[{"name":"Naveris, Inc.  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-0087","authenticated-orcid":false,"given":"Eleni M.","family":"Rettig","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"Sicard","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-0296","authenticated-orcid":false,"suffix":"II","given":"Rocco","family":"Ferrandino","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sida","family":"Chen","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1912-3281","authenticated-orcid":false,"given":"Marshall R.","family":"Posner","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-1484","authenticated-orcid":false,"given":"Krzysztof J.","family":"Misiukiewicz","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-0667","authenticated-orcid":false,"given":"Eric M.","family":"Genden","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-4929","authenticated-orcid":false,"given":"Raymond L.","family":"Chai","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sims","sequence":"additional","affiliation":[{"name":"CARTI Cancer Center  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7690-7686","authenticated-orcid":false,"given":"Elaine","family":"Thrash","sequence":"additional","affiliation":[{"name":"CARTI Cancer Center  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Stern","sequence":"additional","affiliation":[{"name":"CARTI Cancer Center  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Sargent","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-3014","authenticated-orcid":false,"given":"Noah S.","family":"Kalman","sequence":"additional","affiliation":[{"name":"Miami Cancer Institute  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-7989","authenticated-orcid":false,"given":"Sreenija","family":"Yarlagadda","sequence":"additional","affiliation":[{"name":"Miami Cancer Institute  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-7218","authenticated-orcid":false,"given":"John M.","family":"Kaczmar","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Raben","sequence":"additional","affiliation":[{"name":"Helen F. Graham Cancer Center &amp; Research Institute, ChristianaCare  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Clements","sequence":"additional","affiliation":[{"name":"Helen F. Graham Cancer Center &amp; Research Institute, ChristianaCare  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Hockstein","sequence":"additional","affiliation":[{"name":"Helen F. Graham Cancer Center &amp; Research Institute, ChristianaCare  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Bhayani","sequence":"additional","affiliation":[{"name":"Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-0286","authenticated-orcid":false,"given":"Abie H.","family":"Mendelsohn","sequence":"additional","affiliation":[{"name":"Los Angeles Center for Ear, Nose, Throat, and Allergy  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6995"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6833a3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000603\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1937"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29323"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010012\u20100355\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32779\u2010X"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820903031"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34823"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216510"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26396"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.136"},{"issue":"4","key":"e_1_2_10_16_1","first-page":"1703","article-title":"Clinical Outcomes in Patients With Recurrent or Metastatic Human Papilloma Virus\u2010Positive Head and Neck Cancer","volume":"36","author":"Dang R. P.","year":"2016","journal-title":"Anticancer Research"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34562"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.6414"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33215"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2022.106679"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0720\u2010048X(99)00120\u20105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.181"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815621742"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta21170"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.08.011"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.22.28120"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25425"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010020\u201002330\u2010y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106874"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201022\u20100562"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201023\u20101478"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201024\u20103053"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.03.232"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.1937"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201023\u20101064"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmrs.720"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201019\u20100211"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767\u20109764.CRC\u201025\u20100180"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2025.1606"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34109"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010010\u20100985\u20104"},{"key":"e_1_2_10_42_1","volume-title":"AJCC Cancer Staging Manual","author":"Amin M. B.","year":"2017"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/diagnostics13040725","article-title":"Analytical Validation of NavDx, a cfDNA\u2010Based Fragmentomic Profiling Assay for HPV\u2010Driven Cancers","volume":"13","author":"Gunning A.","year":"2023","journal-title":"Diagnostics"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.02.012"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109773"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201004307\u20103"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6191"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201063180\u20108"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27992"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2025.107608"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.20935\/AcadOnco7456"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2023.2274123"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18132034"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aec1724"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1172108"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010023\u201002445\u20101"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70943"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000967\u2010y"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02301"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:02:05Z","timestamp":1791435725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":58,"alternative-id":["10.1002\/hed.70483"],"URL":"https:\/\/doi.org\/10.1002\/hed.70483","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70483"}}