{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:53:47Z","timestamp":1791258827505,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cisplatin\u2010 and carboplatin\u2010based regimens are widely used in the treatment of head and neck squamous cell carcinoma (HNSCC), yet comparative evidence on survival and toxicity outcomes remains limited. While cisplatin is standard in many settings, carboplatin is often preferred in patients with comorbidities or impaired renal function. This systematic review and meta\u2010analysis aimed to synthesize available evidence comparing cisplatin versus carboplatin in HNSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in PubMed, Embase, and the Cochrane Library from inception to February 2026. Randomized and observational studies comparing cisplatin\u2010 and carboplatin\u2010based regimens in HNSCC were included. Primary outcomes were overall survival (OS), progression\u2010free survival (PFS), locoregional recurrence\u2010free survival at 1, 3, and 5\u2009years and distant metastasis\u2010free survival (DMFS) at 1 and 3\u2009years. Secondary outcomes include grade \u2265\u20093 toxicities. Data were pooled using random\u2010effects meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies comprising 1044 patients were included, including four recently published studies not previously pooled in head\u2010to\u2010head analyses. Pooled analyses showed no statistically significant differences between cisplatin and carboplatin in OS, PFS, LRRFS, or DMFS overall. Subgroup analyses across 1, 3, and 5\u2010year follow\u2010up intervals likewise demonstrated no significant differences for most outcomes. The only significant finding was a modest difference in 5\u2010year LRRFS favoring cisplatin, based on only two studies. No statistically significant differences were observed in grade \u2265\u20093 anemia, leukopenia, thrombocytopenia, or nausea\/vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cisplatin and carboplatin\u2010based regimens yield largely comparable survival and toxicity outcomes in HNSCC. Treatment selection should be guided by patient comorbidities and tolerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70485","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:41:35Z","timestamp":1791258095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Cisplatin Versus Carboplatin for Patients With Squamous Cell Carcinoma of Head and Neck: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0909-625X","authenticated-orcid":false,"given":"Samiya","family":"Rahim","sequence":"first","affiliation":[{"name":"Department of Medicine Ayub Medical College  Abbottabad 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