{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:47:08Z","timestamp":1791784028283,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stereotactic body radiotherapy (SBRT) is used for reirradiation in recurrent or metastatic head and neck squamous cell carcinoma (RM\u2010HNSCC), but prognostic factors remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 36 RM\u2010HNSCC patients treated with CyberKnife\u2010SBRT (2009\u20132022). Endpoints: local control (LC) and overall survival (OS), estimated using Kaplan\u2013Meier and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 8.5\u2009months, median OS was 9.6\u2009months, with 1\u2010 and 2\u2010year OS rates of 43.5% and 34.2%. One\u2010 and 2\u2010year LC rates were 55.1% and 34.5%, with median time\u2010to\u2010recurrence of 14.1\u2009months. On multivariable analysis, smoking\u2009&gt;\u200930 pack\u2010years predicted worse LC (HR 5.68; 95% CI, 1.42\u201322.70;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), while former\/never smoking predicted improved OS (HR 0.26; 95% CI, 0.08\u20130.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). Gross tumor volume\u2009&gt;\u200937.0\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      predicted worse LC (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) on univariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Smoking history independently predicted LC and OS; larger tumor volume was associated with worse outcomes and may inform patient selection for SBRT reirradiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70494","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:39:20Z","timestamp":1791783560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CyberKnife<\/scp>\n                    Stereotactic Body Radiotherapy for Reirradiation of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Outcomes and Prognostic Factors"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-0447","authenticated-orcid":false,"given":"Shay","family":"Sharon","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hadassah Medical Center, Faculty of Dental Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-3308","authenticated-orcid":false,"given":"Muhammad M.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Keohan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-4981","authenticated-orcid":false,"given":"Minh Tam","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical Center Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_7_3_1","unstructured":"American Cancer Society \u201cCancer Facts and Figures\u00a02026 \u201d2026 https:\/\/www.cancer.org."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34823"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24633"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123\u2010200301000\u201000018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.325125008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8562"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758\u20103284\u20104\u201012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149\u2010012\u20100604\u20105"},{"key":"e_1_2_7_11_1","unstructured":"L.Kachnic L.Chin andDOD grant. 2007\u20132012; Co\u2010Investigator U.S. Army Medical Research and Material Command Office of Congressionally Directed Medical Research Programs Center of Excellence \u201cThe Application of Emerging Radiosurgical Technology for the Treatment of Cancer Patients From Underserved Communities \u201d$3 870 000."},{"key":"e_1_2_7_12_1","unstructured":"Project Principal Investigator DOD07\u20101\u20100342 Department of Defense Center of Excellence The Feasibility and Outcome of CyberKnife Stereotactic Radiosurgical Boost and Salvage Therapy for Head and Neck Cancer$1 423 423."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.9.FOCUS09199"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/HED.26820"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0B013E3181E84DC0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AMJOTO.2021.102913"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.01.044"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.111283"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104757"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.02.049"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2025.06.3846"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.04.027"},{"key":"e_1_2_7_23_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology","author":"National Comprehensive Cancer Network","year":"2025"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70494","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:39:22Z","timestamp":1791783562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":22,"alternative-id":["10.1002\/hed.70494"],"URL":"https:\/\/doi.org\/10.1002\/hed.70494","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"hed.70494"}}