{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:47:40Z","timestamp":1792133260667,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leiomysosarcoma (LMS) is generally associated with high metastatic potential and poor survival. Cutaneous LMS (cLMS) has been considered a different entity with more indolent biological behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review was performed to assess the biological behavior of cLMS, with special attention for the head and neck location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>cLMS is located in the head and neck in 21%\u201333%. The local recurrence rate is 2%\u201318%, while only 3% develops metastatic disease at 10\u2009years. The most important risk factor of recurrent disease is positive\/close surgical margins, with a trend for increased risk at the head and neck. The vast majority of recurrences are local and appear during the first few years. No data support adjuvant treatment. The 5\u2010year disease\u2010specific survival is 96%\u2013100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>cLMS exhibits a moderate risk of local recurrence, low metastatic potential, and excellent disease\u2010specific survival. Surveillance may be focused on physical examination and limited in duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70512","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:20:04Z","timestamp":1792131604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Leiomyosarcoma of the Head and Neck: Appreciation of a More Indolent Biological Behavior and\u00a0Implications for Its Management"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-3727","authenticated-orcid":false,"given":"Eelco","family":"de Bree","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Medical School of Crete University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-5814","authenticated-orcid":false,"given":"Remco","family":"de Bree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-9464","authenticated-orcid":false,"given":"Carlos","family":"Chiesa\u2010Estomba","sequence":"additional","affiliation":[{"name":"ENT\u2010Head and Neck Department Hospital Universitario Donostia  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4050-9106","authenticated-orcid":false,"given":"M. P.","family":"Sreeram","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology Sri Shankara Cancer Hospital and Research Center, Sri Shankara Cancer Foundation  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-2664","authenticated-orcid":false,"given":"Dimosthenis","family":"Michelakis","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Medical School of Crete University Hospital  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-7366","authenticated-orcid":false,"given":"Karthik N.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology Sri Shankara Cancer Hospital and Research Center, Sri Shankara Cancer Foundation  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-6709","authenticated-orcid":false,"given":"Alessandra","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"ENT Unit Policlinico Citt\u00e0 di Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-8002","authenticated-orcid":false,"given":"Alfio","family":"Ferlito","sequence":"additional","affiliation":[{"name":"Coordinator of the International Head and Neck Scientific Group  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-002-0050-y"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.oraloncology.2010.09.001","article-title":"Management of Adult Soft Tissue Sarcomas of the Head and Neck","volume":"46","author":"Bree R.","year":"2010","journal-title":"Oral Oncology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818768495"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545747"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.11.014"},{"key":"e_1_2_12_7_1","first-page":"169","article-title":"Sarcomas of the Head and Neck","volume":"70","author":"Tran L. 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