{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:04Z","timestamp":1792809484270,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n G\u2010tube placement timing remains poorly characterized in patients with localized head and neck cancer (HNSCC) undergoing definitive chemoradiation (dCRT).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively analyzed 144 patients with HNSCC who received dCRT (2019\u20132024), categorized by \u201cupfront\u201d or \u201cas\u2010needed\u201d G\u2010tube strategy, to explore factors associated with timing and outcomes using propensity score weighting.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most patients were White (85%) and male (83%); median age was 63\u2009years. Upfront G\u2010tube placement occurred in 60 patients (42%) and was more common among women (64% vs. 37%,\n p<\/jats:italic>\n \u2009=\u20090.015) and those with dysphagia (55% vs. 28%,\n p<\/jats:italic>\n \u2009=\u20090.001) or receiving induction chemotherapy (71% vs. 38%,\n p<\/jats:italic>\n \u2009=\u20090.023). dCRT duration, weight loss, ED visits, hospitalizations, ICU admissions, and survival did not differ. Upfront placement was associated with lower odds of chemotherapy modification (73% lower,\n p<\/jats:italic>\n \u2009=\u20090.007) and fewer infusion clinic visits (average 3 fewer,\n p<\/jats:italic>\n \u2009=\u20090.038).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings suggest multiple factors influence G\u2010tube timing and outcomes, warranting prospective validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.70518","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:47:58Z","timestamp":1792806478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring G\u2010Tube Timing and Clinical Outcomes in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Chemoradiation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-9775","authenticated-orcid":false,"given":"Cameron","family":"Chalker","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health & Science University (OHSU), Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Burton","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology OHSU, Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-6936","authenticated-orcid":false,"given":"Andy","family":"Kaempf","sequence":"additional","affiliation":[{"name":"Cancer Data Science Shared Resource OHSU, Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5503-998X","authenticated-orcid":false,"given":"Jeong Youn","family":"Lim","sequence":"additional","affiliation":[{"name":"Cancer Data Science Shared Resource OHSU, Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-4778","authenticated-orcid":false,"given":"Sarah","family":"Lowry","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health & Science University (OHSU), Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erynn A.","family":"Beeson","sequence":"additional","affiliation":[{"name":"Division of Palliative Medicine University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8104-0754","authenticated-orcid":false,"given":"Katherine","family":"Bagwell","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition OHSU, Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Mitin","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology OHSU, Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4656-734X","authenticated-orcid":false,"given":"Chetan V.","family":"Vakkalagadda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health & Science University (OHSU), Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Cetnar","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health & Science University (OHSU), Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-3573","authenticated-orcid":false,"given":"Eric J.","family":"Roeland","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Oregon Health & Science University (OHSU), Knight Cancer Institute Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and Neck Cancer","volume":"382","author":"Chow L. Q.","year":"2020","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and Neck Squamous Cell Carcinoma","volume":"6","author":"Johnson D. E.","year":"2020","journal-title":"Nature Reviews. Disease Primers"},{"issue":"20","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1200\/JCO.18.01921","article-title":"Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline","volume":"37","author":"Koyfman S. A.","year":"2019","journal-title":"Journal of Clinical Oncology"},{"issue":"36","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1200\/JCO.2017.73.8633","article-title":"Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence\u2010Based Clinical Practice Guideline","volume":"35","author":"Quon H.","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"9","key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1002\/hed.26315","article-title":"Association Between Nutritional Risk Index and Outcomes for Head and Neck Cancer Patients Receiving Concurrent Chemo\u2010Radiotherapy","volume":"42","author":"Oh J.","year":"2020","journal-title":"Head & Neck"},{"issue":"8","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hed.20221","article-title":"Impact of Nutrition on Outcome: A Prospective Randomized Controlled Trial in Patients With Head and Neck Cancer Undergoing Radiotherapy","volume":"27","author":"Ravasco P.","year":"2005","journal-title":"Head & Neck: Journal for the Sciences and Specialties of the Head and Neck"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(25)00087\u20107"},{"issue":"2","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/019459988309100203","article-title":"Patterns of Nutritional Deficiency in Head and Neck Cancer","volume":"91","author":"Bassett M. 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