{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:41:47Z","timestamp":1792467707014,"version":"4.5.0"},"reference-count":96,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["140909\/2025\u20107"],"award-info":[{"award-number":["140909\/2025\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To characterize the clinicoepidemiologic profile of HIV\u2010associated oral Kaposi sarcoma (OKS) and quantitatively synthesize its frequency, anatomical distribution, and temporal patterns across antiretroviral therapy (ART) eras.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six databases and gray literature were searched. Eligible observational, descriptive, and quasi\u2010experimental studies were appraised using JBI tools. Random\u2010effects meta\u2010analyses of patient\u2010based proportions and treatment\u2010era subgroup were performed when compatible study\u2010level denominators were available (PROSPERO: CRD420251105061).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight studies comprising 1661 individuals were included, and 31 contributed to at least one meta\u2010analysis. Pooled proportions were 0.85 (95% CI: 0.76\u20130.91) for palatal involvement and 0.44 (95% CI: 0.23\u20130.68) for OKS as a sentinel presentation of HIV. Pooled prevalence of OKS among people living with HIV was 0.06 (95% CI: 0.02\u20130.12). Compared with the pre\u2010combination ART era, the combination ART era showed lower palatal (0.72 vs. 0.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0034) and gingival involvement (0.07 vs. 0.30;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003), but more sentinel presentations (0.72 vs. 0.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0195). Methodological quality was moderate, with substantial heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pooled evidence confirms strong palatal predilection of HIV\u2010associated OKS. Temporal subgroup findings suggest changes in oral distribution across ART eras while reinforcing its persistent role as a sentinel manifestation of HIV infection and persistent clinical relevance despite ART.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70520","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:34:23Z","timestamp":1792467263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicoepidemiologic Profile of Oral Kaposi Sarcoma in People Living With\n                    <scp>HIV<\/scp>\n                    : A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-3146","authenticated-orcid":false,"given":"Ericles","family":"Ot\u00e1vio","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis and Pathology School of Dentistry, Universidade Federal do Rio de Janeiro 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