{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:39:58Z","timestamp":1792647598809,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We evaluated outcomes and complications of transoral CO\n                      <jats:sub>2<\/jats:sub>\n                      laser microsurgery (TLM) for hypopharyngeal tumors and its feasibility in \u2265\u200975\u2010year\u2010old patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 116 patients (without metastases) treated from February 2012 to October 2024 at our hospital. Oncologic outcomes were analyzed using Kaplan\u2013Meier curves (110 patients; median follow\u2010up: 5.3\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five\u2010year local control, disease\u2010specific survival, and overall survival rates were 87.8%, 94.6%, and 85.6%, respectively. Postoperative dysphagia, aspiration pneumonia, pharyngolaryngeal edema, and vocal fold paralysis occurred in 9%, 4%, 3%, and 3% of patients, respectively; none required tracheostomy or surgical hemostasis under general anesthesia. The group with a history of head and neck irradiation had higher rates of dysphagia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and aspiration pneumonia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) than those without. Differences between age groups were nonsignificant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TLM appears safe and effective for older patients with appropriately selected hypopharyngeal tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70523","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:23:36Z","timestamp":1792646616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oncologic Outcomes and Treatment Feasibility of Transoral Carbon Dioxide Laser Microsurgery for Hypopharyngeal Tumors in Older Patients: A Retrospective Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-7034","authenticated-orcid":false,"given":"Takeharu","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-2331","authenticated-orcid":false,"given":"Shun\u2010ichi","family":"Chitose","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-4612","authenticated-orcid":false,"given":"Takashi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-7590","authenticated-orcid":false,"given":"Fumihiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mioko","family":"Fukahori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Sueyoshi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunehiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taikai","family":"Kuroiwa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-495X","authenticated-orcid":false,"given":"Hirohito","family":"Umeno","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12031237","article-title":"Current Therapeutic Strategies for Patients With Hypopharyngeal Carcinoma: Oncologic and Functional Outcomes","volume":"12","author":"Bozec A.","year":"2023","journal-title":"Journal of Clinical Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.oraloncology.2018.09.025","article-title":"Hypopharyngeal Cancer: A State of the Art Review","volume":"86","author":"Garneau J. C.","year":"2018","journal-title":"Oral Oncology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12955-020-1281-z","article-title":"Quality of Life After Total Laryngectomy: Impact of Different Vocal Rehabilitation Methods in a Middle Income Country","volume":"18","author":"Souza F. G. R.","year":"2020","journal-title":"Health and Quality of Life Outcomes"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1053\/j.seminoncol.2004.09.006","article-title":"Concurrent Chemoradiotherapy for Head and Neck Cancer","volume":"31","author":"Brockstein B.","year":"2004","journal-title":"Seminars in Oncology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer","volume":"349","author":"Forastiere A. 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A.","year":"2012","journal-title":"Current Oncology Reports"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000045617","article-title":"Developments in Diagnosis and Treatment of Early Hypopharyngeal Carcinoma and Precancerous Lesions: A Review","volume":"104","author":"Cheng J.","year":"2025","journal-title":"Medicine"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.804933","article-title":"Current Status of Transoral Surgery for Patients With Early\u2010Stage Pharyngeal and Laryngeal Cancers in Japan","volume":"11","author":"Sano D.","year":"2021","journal-title":"Frontiers in Oncology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1002\/cam4.3927","article-title":"Transoral Surgery for Superficial Head and Neck Cancer: National Multi\u2010Center Survey in Japan","volume":"10","author":"Katada C.","year":"2021","journal-title":"Cancer Medicine"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0196-0709(93)90050-H","article-title":"Results of Curative Laser Microsurgery of Laryngeal Carcinomas","volume":"14","author":"Steiner W.","year":"1993","journal-title":"American Journal of Otolaryngology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.anl.2015.06.013","article-title":"Transoral Surgery for Laryngo\u2010Pharyngeal Cancer\u2014The Paradigm Shift of the Head and Cancer Treatment","volume":"43","author":"Tateya I.","year":"2016","journal-title":"Auris Nasus Larynx"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/ggi.13118","article-title":"Redefining the Elderly as Aged 75\u2009Years and Older: Proposal From the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society","volume":"17","author":"Ouchi Y.","year":"2017","journal-title":"Geriatrics & Gerontology International"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/MOO.0000000000000526","article-title":"Systemic Treatment in Elderly Head and Neck Cancer Patients: Recommendations for Clinical Practice","volume":"27","author":"Szturz P.","year":"2019","journal-title":"Current Opinion in Otolaryngology & Head and Neck Surgery"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2147\/CIA.S475037","article-title":"Transoral Laser Microsurgery and Transoral Robotic Surgery in Aging Patients: A State\u2010of\u2010the\u2010Art Review","volume":"19","author":"Lechien J. R.","year":"2024","journal-title":"Clinical Interventions in Aging"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/lary.25965","article-title":"Histoanatomical Characteristics to Increase the Success in Transoral Surgery for Hypopharyngeal Cancer","volume":"126","author":"Chitose S.","year":"2017","journal-title":"Laryngoscope"},{"key":"e_1_2_11_17_1","unstructured":"Japan Clinical Oncology Group JCOG Postoperative Complications Criteria (Clavien\u2010Dindo Classification) Version 2.0."},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3950\/jibiinkoka.122.891","article-title":"Short\u2010Term Outcomes of Endoscopic Laryngo\u2010Pharyngeal Surgery (ELPS) for Superficial Head and Neck Cancer","volume":"122","author":"Sato H.","year":"2019","journal-title":"Nippon Jibiinkoka Gakkai Kaiho"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104655","article-title":"Endoscopic Laryngopharyngeal Surgery for Hypopharyngeal Lesions","volume":"106","author":"Kishimoto Y.","year":"2020","journal-title":"Oral Oncology"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-017-3396-0","article-title":"Clinical Outcomes of Transoral Videolaryngoscopic Surgery for Hypopharyngeal and Supraglottic Cancer","volume":"17","author":"Imanishi Y.","year":"2017","journal-title":"BMC Cancer"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.oraloncology.2018.09.014","article-title":"Oncological and Functional Outcomes of Trans\u2010Oral Robotic Surgery for Pyriform Sinus Carcinoma: A French GETTEC Group Study","volume":"86","author":"Mazerolle P.","year":"2018","journal-title":"Oral Oncology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.oraloncology.2017.06.016","article-title":"The Long\u2010Term Oncological and Functional Outcomes of Transoral Robotic Surgery in Patients With Hypopharyngeal Cancer","volume":"71","author":"Park Y. 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