{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:08:20Z","timestamp":1788433700583,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["222167"],"award-info":[{"award-number":["222167"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Advancements in treatments have significantly improved the prognosis for mantle cell lymphoma (MCL), and there is a growing population of survivors with an increased susceptibility to infections. We assessed the incidence of infections by clinical characteristics and treatment both before and after MCL diagnosis in Sweden. Patients with a diagnosis of MCL\u2009\u2265\u200918 years between 2007 and 2019 were included, along with up to 10 matched comparators. Infectious disease diagnosis and anti\u2010infective drug dispensation were identified by the National Patient and the Prescribed Drug Registers, respectively. Patients and comparators were followed from the diagnosis\/matching date until death, emigration, or June 30, 2020. Overall, 1559 patients and 15,571 comparators were followed for a median duration of 2.9 and 5 years, respectively. The infection rate among patients was twofold higher, RRadj\u2009=\u20092.14 (2.01\u20132.27), contrasted to the comparator group. There was a notable rise in infection rates already 4 years before MCL diagnosis, which reached a fourfold increase in the first year after diagnosis and persisted significantly increased for an additional 8 years. Among patients, 69% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091080) experienced at least one infection during the first year of follow\u2010up. Influenza, pneumonia, other bacterial infections, urinary tract infections, and acute upper respiratory infections were the most frequent. Notably, MCL remained to be the primary leading cause of death among patients (57%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009467\/817). Infections as the main cause of death were rare (2.6%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921). Our study highlights the importance of thoroughly assessing infectious morbidity when appraising new treatments. Further investigations are warranted to explore strategies for reducing infectious disease burden.\n                  <\/jats:p>","DOI":"10.1002\/hem3.121","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:25:30Z","timestamp":1720416330000},"source":"Crossref","is-referenced-by-count":8,"title":["Infections in patients with mantle cell lymphoma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-0215","authenticated-orcid":false,"given":"Kossi D.","family":"Abalo","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University  Uppsala Sweden"},{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ekberg","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University  Uppsala Sweden"},{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese M. L.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Pahnke","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-8594","authenticated-orcid":false,"given":"Alexandra","family":"Albertsson\u2010Lindblad","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Clinical Sciences Lund, Sk\u00e5ne University Hospital Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Clinical Sciences Lund, Sk\u00e5ne University Hospital Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-3041","authenticated-orcid":false,"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University  Uppsala Sweden"},{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007241"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1919662"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063368"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00035-19"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0178"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/605664"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004286"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac574"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000928"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.587560"},{"key":"e_1_2_10_12_1","unstructured":"Regionala Cancer Centrum (RCC).Nationella kvalitetsregistret f\u00f6r lymfom diagnosperioden 2000\u22122021;2022. 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