{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:31:22Z","timestamp":1787509882371,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Results of a prospective study of stage\u2010adapted treatment of human\u00a0immunodeficiency virus (HIV)\u2010associated Hodgkin lymphoma (HIV\u2010HL) showed a 2\u2010year overall survival (OS) of 90.7% with no significant difference between early favorable (EF), early unfavorable (EU), and advanced HL. Patients with EF HIV\u2010HL received two to four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)\u2009+\u200930\u2009Gy involved field (IF) radiation, those with EU HIV\u2010HL received four cycles of ABVD or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) baseline\u2009+\u200930\u2009Gy IF, and six to eight cycles of BEACOPP baseline were administered in advanced disease. The objective of the present analysis is to determine long\u2010term outcomes of HIV\u2010HL. Of 108 patients, 23 (21%) had EF HL, 14 (13%) had EU HL, and 71 (66%) had advanced\u2010stage HL. After a median follow\u2010up of 9.14 (range, 0\u201312.9) years, there were five primary refractory HL patients (5%) and 11 relapses (10%), of which seven were late relapses (&gt;2 years). A second primary malignancy (SPM) occurred in 10 patients after a median of 7.3 years (range, 1.5\u201310.7) from HL diagnosis. The 10\u2010year OS for patients with EF, EU, and advanced HL was 95.7%, 84.6%, and 76.1%, respectively. By multivariate analysis, Center for Disease Control and Prevention category C (hazard ratio [HR]\u00a03.00, 95% confidence interval [CI]:\u00a01.16\u20137.74,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023) and achievement of complete remission were significant for OS (HR 0.03, 95% CI: 0.01\u20130.08,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20092.45\u2009\u00d7\u200910\n                    <jats:sup>\u22129<\/jats:sup>\n                    ). In conclusion, a stage\u2010adapted treatment approach for HIV\u2010HL is highly effective with long\u2010term survival rates similar to those reported in HIV\u2010uninfected HL. However, the risk for late relapse and SPM is significant.\n                  <\/jats:p>","DOI":"10.1002\/hem3.68","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T14:38:54Z","timestamp":1720017534000},"source":"Crossref","is-referenced-by-count":4,"title":["Stage\u2010adapted treatment of HIV\u2010associated Hodgkin lymphoma: Long\u2010term results of a prospective, multicenter study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-348X","authenticated-orcid":false,"given":"Marcus","family":"Hentrich","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Red Cross Hospital Ludwig\u2010Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Joseph's Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wyen","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pferschy","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Red Cross Hospital Ludwig\u2010Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vindi","family":"Jurinovic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Ludwig\u2010Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Siehl","sequence":"additional","affiliation":[{"name":"\u00c4rzteforum Seestra\u00dfe Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen K.","family":"Rockstroh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pulmonary Medicine Charit\u00e9\u2014University Medicine Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"ICH Study Center Hamburg Germany"},{"name":"Department of Internal Medicine II University Hospital of Schleswig Holstein, Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the German HIV\u2010Related Lymphoma Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174366"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1045"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30118-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx249"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000980"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.4193"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ627"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001487"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0989"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.41.8137"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1201573"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00157-6"},{"key":"e_1_2_9_14_1","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"5","author":"US Centers for Disease Control and Prevention","year":"1993","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy080"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.5807"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00029-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10479"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3298"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30140-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61940-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00935"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206125"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00177-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2613-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00674-w"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.3289"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18180"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.2020775"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00137-6"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29066"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0480-x"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.68","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:10:06Z","timestamp":1763658606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.68"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/hem3.68"],"URL":"https:\/\/doi.org\/10.1002\/hem3.68","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"article-number":"e68"}}