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In the pediatric context, the\n                    <jats:italic>NUP98<\/jats:italic>\n                    gene is a frequent target of chromosomal rearrangements that are linked to poor prognosis and unfavorable treatment outcomes in different AML subtypes. The translocations fuse\n                    <jats:italic>NUP98<\/jats:italic>\n                    to a diverse array of partner genes, resulting in fusion proteins with novel functions. NUP98 fusion oncoproteins induce aberrant biomolecular condensation, abnormal gene expression programs, and re\u2010wired protein interactions which ultimately cause alterations in the cell cycle and changes in cellular structures, all of which contribute to leukemia development. The extent of these effects is steered by the functional domains of the fusion partners and the influence of concomitant somatic mutations. In this review, we discuss the complex characteristics of NUP98 fusion proteins and potential novel therapeutic approaches for NUP98 fusion\u2010driven AML.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70013","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T11:34:17Z","timestamp":1727264057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities"],"prefix":"10.1002","volume":"8","author":[{"given":"Milad","family":"Rasouli","sequence":"first","affiliation":[{"name":"Princess Maxima Center for Pediatric Oncology Utrecht The Netherlands"},{"name":"Department of Pediatric Hematology\/Oncology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Troester","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Grebien","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology University of Veterinary Medicine Vienna Vienna Austria"},{"name":"St. Anna Children's Cancer Research Institute (CCRI) Vienna Austria"},{"name":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca F.","family":"Goemans","sequence":"additional","affiliation":[{"name":"Princess Maxima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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