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Utilizing cause\u2010specific flexible parametric survival models, we estimated cause\u2010specific hazard ratios (HRs) and cumulative incidences of death due to CLL, solid malignancies, other hematological malignancies, infections, and other causes. Our findings reveal CLL as the predominant COD, contributing to around 40% of relative mortality, with a declining 5\u2010year death probability from 16.8% in 1996\u20132002 to 7.6% in 2010\u20132020. Also, deaths attributed to solid malignancies, other hematological malignancies, and other COD diminished over time, as evidenced by respective HRs (95% confidence interval) of 0.68 (0.60%\u20130.77%), 0.45 (0.38%\u20130.53%), and 0.77 (0.66%\u20130.90%). In summary, our comprehensive, population\u2010based analysis underscores a noticeable reduction in CLL\u2010attributed deaths and other competing causes over the studied period. Nonetheless, CLL is registered as the most prevalent cause of mortality among contemporary diagnosed patients with CLL, emphasizing the continued relevance of CLL\u2010centric clinical strategies and research.<\/jats:p>","DOI":"10.1002\/hem3.70015","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T08:20:44Z","timestamp":1731399644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Causes of death among patients diagnosed with chronic lymphocytic leukemia: A population\u2010based study in the Netherlands, 1996\u20132020"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-1203","authenticated-orcid":false,"given":"Lina","family":"van der Straten","sequence":"first","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL) Utrecht The Netherlands"},{"name":"Department of Internal Medicine Albert Schweitzer Hospital Dordrecht The Netherlands"},{"name":"Department of Immunology Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u2010David","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Albert Schweitzer Hospital Dordrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manette A. 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