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We included 2701 patients with acute lymphoblastic leukemia (ALL) and 9027 patients with acute myeloid leukemia (AML) who underwent HCT between 2005 and 2012. The 10\u2010year overall survival (OS) rate was 81.3% for ALL and 76.2% for AML, with the main causes of late mortality being relapse (ALL\u201033.9%, AML\u201044.9%) and chronic graft\u2010versus\u2010host disease (ALL\u201029%, AML\u201018%). At 10 years, HCT\u2010related mortality was 16.8% and 20.4%, respectively. Older age and unrelated donor transplantation were associated with a worse prognosis for both types of leukemia. In addition, transplantation in the second or third complete remission and peripheral blood HSC for ALL are associated with worse outcomes. Similarly, adverse cytogenetics, female donor to male patient combination, and reduced intensity conditioning in AML contribute to poor prognosis. We conclude that 2\u2010year survival in remission after HCT for acute leukemia is encouraging, with OS of nearly 80% at 10 years. However, the long\u2010term mortality risk of HCT survivors remains significantly higher than that of the age\u2010matched general population. These findings underscore the importance of tailoring transplantation strategies to improve long\u2010term outcomes in patients with acute leukemia undergoing HCT.<\/jats:p>","DOI":"10.1002\/hem3.70026","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:08:32Z","timestamp":1729580912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term outcome of 2\u2010year survivors after allogeneic hematopoietic cell transplantation for acute leukemia"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4810-045X","authenticated-orcid":false,"given":"Marion","family":"Larue","sequence":"first","affiliation":[{"name":"Hematology Department H\u00f4pital Saint\u2010Antoine, APHP Paris France"},{"name":"INSERM UMRs 938 Sorbonne University Paris 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