{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:57:33Z","timestamp":1787669853916,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study examines the impact of cytogenetic abnormalities and their co\u2010segregation on the prognosis of newly diagnosed multiple myeloma patients. The analysis included 1304 patients from four different GEM\u2010PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells. The frequency of genetic alterations detected were as follows: del(17p) in 8%, t(4;14) in 12%, t(14;16) in 3%, +1q in 43%, and del(1p) in 8%. The median follow\u2010up was 61 months, and the median progression\u2010free survival (PFS) and overall survival (OS) were 44 months and not reached, respectively. Consistent with previous reports, the presence of t(4;14) was associated with shorter PFS and OS. In our series, the presence of t(14;16) did not impact survival, maybe due to limitations in sample size. Del(17p) was linked to poor prognosis using a cut\u2010off level of \u226520% positive cells, without any impact of higher cut\u2010off in prognosis, except for patients with clonal fraction \u226580% who had a dismal outcome. Cosegregation of cytogenetic abnormalities patients worsened the prognosis in t(4;14) patients but not in patients with del(17p), which retained its adverse prognosis even as a solitary abnormality. Gain(1q) was associated with significantly shorter PFS and OS, while del(1p) affected PFS but not OS. Nevertheless, when co\u2010segregation was eliminated, the detrimental effect of +1q or del(1p) was no longer observed. In conclusion, this study confirms the prognostic significance of high\u2010risk cytogenetic abnormalities in MM and highlights the importance of considering co\u2010occurrence for accurate prognosis assessment.<\/jats:p>","DOI":"10.1002\/hem3.70031","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:10:03Z","timestamp":1733883003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High\u2010risk cytogenetic abnormalities in multiple myeloma: PETHEMA\u2010GEM experience"],"prefix":"10.1002","volume":"8","author":[{"given":"Veronica","family":"Gonz\u00e1lez\u2010Calle","sequence":"first","affiliation":[{"name":"Department of Hematology, Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigaci\u00f3n del Cancer (IBMCC\u2010USAL, CSIC) CIBERONC Salamanca 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