{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:55:04Z","timestamp":1792587304835,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SPP microbone"],"award-info":[{"award-number":["SPP microbone"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idecabtagene vicleucel (ide\u2010cel) and ciltacabtagene autoleucel (cilta\u2010cel) have revolutionized the treatment of relapsed\/refractory multiple myeloma (RRMM), but direct comparisons are lacking. Leveraging an international multicenter RRMM cohort, we compared the outcome of ide\u2010cel (<jats:italic>n<\/jats:italic>\u2009=\u2009162) versus cilta\u2010cel (<jats:italic>n<\/jats:italic>\u2009=\u200942). Co\u2010primary efficacy endpoints of the study were overall response rate (ORR) and progression\u2010free survival (PFS). Co\u2010primary safety endpoints were the incidence of cytokine release syndrome (CRS) and immune\u2010effector cell\u2010associated neurotoxicity syndrome (ICANS). Median turnaround time between apheresis and infusion was 47 days for ide\u2010cel versus 68 days for cilta\u2010cel (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Cilta\u2010cel showed significantly higher ORR (93% vs. 79%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with complete response at Day 30 of 48% versus 26% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The 10\u2010month PFS and overall survival (OS) was 82% and 90% for cilta\u2010cel versus 47% and 77% ide\u2010cel (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>p<\/jats:italic>\u2009=\u20090.06), and improved outcome for cilta\u2010cel was confirmed after multivariable adjustment. Incidence of CRS and ICANS appeared similar (81% and 19% for cilta\u2010cel versus 85% and 19% for ide\u2010cel), while 10% and 7% in the cilta\u2010cel group versus 4% and 2% in the ide\u2010cel group showed severe CRS and ICANS grade 3\u20134, with CRS occurring significantly earlier for ide\u2010cel (median, 2 days vs. 4 days; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Nonrelapse mortality was 5% for cilta\u2010cel versus 3% for ide\u2010cel (<jats:italic>p<\/jats:italic>\u2009=\u20090.51). Cilta\u2010cel showed later peak of CAR\u2010T expansion at Day 14 versus Day 7 for ide\u2010cel, while cilta\u2010cel expansion was associated with ICANS. Our study provides real\u2010world evidence that cilta\u2010cel was associated with superior outcomes and distinct cellular dynamics versus ide\u2010cel in triple\u2010class exposed RRMM.<\/jats:p>","DOI":"10.1002\/hem3.70070","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T08:12:49Z","timestamp":1737015169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Idecabtagene vicleucel or ciltacabtagene autoleucel for relapsed or refractory multiple myeloma: An international multicenter study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-5973","authenticated-orcid":false,"given":"Maximilian","family":"Merz","sequence":"first","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases Universit\u00e4tsklinikum Leipzig Leipzig 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Fenk","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr H\u00e4matologie, Onkologie und Klinische Immunologie, Heinrich Heine University University Hospital D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Holderried","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik III \u2013 Innere Medizin mit den Schwerpunkten Onkologie, H\u00e4matologie, Immunonkologie und Rheumatologie Universit\u00e4tsklinikum Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-5839","authenticated-orcid":false,"given":"Fabian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen Friedrich\u2010Alexander University of Erlangen\u2010Nuremberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tovar","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Hospital Cl\u00ednic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Oliver\u2010C\u00e1ldes","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Hospital Cl\u00ednic de Barcelona Barcelona Spain"},{"name":"IDIBAPS Hospital Universitari Son Espases, Palma de Mallorca  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-285X","authenticated-orcid":false,"given":"Vladan","family":"Vucinic","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases Universit\u00e4tsklinikum Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Kharboutli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5, Haematology and Oncology, University Hospital of Erlangen Friedrich\u2010Alexander University of Erlangen\u2010Nuremberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben\u2010Niklas","family":"B\u00e4rmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr H\u00e4matologie, Onkologie und Klinische Immunologie, Heinrich Heine University University Hospital D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Ayuk","sequence":"additional","affiliation":[{"name":"Interdisziplin\u00e4re Klinik und Poliklinik f\u00fcr Stammzelltransplantation University Medical Center Hamburg\u2010Eppendorf Hamburg 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