{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:27:33Z","timestamp":1787509653022,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001646","name":"Robert Bosch Stiftung","doi-asserted-by":"publisher","award":["O3"],"award-info":[{"award-number":["O3"]}],"id":[{"id":"10.13039\/501100001646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diffuse large B\u2010cell lymphoma (DLBCL) is the most common non\u2010Hodgkin lymphoma. Despite a high cure rate, too many patients show refractory (ref) or relapsed (rel) disease. This study examines the frequency of recurring gene mutations and their interplay with well\u2010known biomarkers in female and male patients between 18 and 80 years with ref\/rel DLBCL compared to patients with complete remission (CR) to identify biological risk factors associated with treatment response, using cohorts of R\u2010CHOP\u2010like treated DLBCL enrolled in clinical trials of the DSHNHL. The biomarker profile of patients differed between younger and elderly patients with ref\/rel DLBCL, with a higher frequency of\n                    <jats:italic>BCL2<\/jats:italic>\n                    translocations in younger patients, and higher numbers of ABC subtypes and MYC protein expression in the elderly. Amplicon sequencing revealed generally higher mutation frequencies in the younger cohort. Mutations in\n                    <jats:italic>CREBBP<\/jats:italic>\n                    and\n                    <jats:italic>TNFRSF14<\/jats:italic>\n                    were associated with shorter overall survival (OS) only in younger patients. A higher proportion of\n                    <jats:italic>GNA13<\/jats:italic>\n                    mutations was detected in female patients of the elderly DLBCL patient cohort, clearly emphasizing the striking differences in biomarker distribution between younger and elderly as well as female and male patients.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70093","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:54:32Z","timestamp":1741726472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age\u2010 and gender\u2010specific molecular characteristics of diffuse large B\u2010cell lymphoma: Results from clinical trials of the DSHNHL\/GLA"],"prefix":"10.1002","volume":"9","author":[{"given":"Katrin S.","family":"Kurz","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Steinlein","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology Stuttgart and University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kreuz","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics, and Epidemiology Universit\u00e4t Leipzig Leipzig Germany"},{"name":"Department of Diagnostics Fraunhofer Institute for Cell Therapy and Immunology Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Ziepert","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics, and Epidemiology Universit\u00e4t Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Staiger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart Germany"},{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology Stuttgart and University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F. 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