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Talquetamab, a GPRC5DxCD3 BTCE, has shown promising results in the MonumenTAL\u20101 trial and was recently approved by the Food and Drug Administration and the European Medicines Agency. However, treatment under real\u2010world conditions may not represent patient characteristics in clinical trials with restricted enrollment criteria. We performed a retrospective real\u2010world analysis including 138 RRMM patients treated with talquetamab at 21 German centers. Of evaluable patients, 43% had ISS stage III, 37% had extraosseous disease, and 48% had high\u2010risk cytogenetics. After a median of six prior therapy lines, 58% of patients would not have been eligible for MonumenTAL\u20101. With a median follow\u2010up of 8.2 months, we observed an overall response rate of 65% and a median progression\u2010free survival of 6.4 months (95% confidence interval 5.1\u20139.0). Prior BTCE exposure, ISS stage III, extraosseous disease, and penta\u2010drug refractory disease were associated with unfavorable outcomes. Grade\u2009\u2265\u20093 cytokine release syndrome and neurotoxicity occurred in 5.1% and 1.5% of patients, respectively. In summary, our real\u2010world study confirms the efficacy and safety of talquetamab, despite a high proportion of patient\u2010 and disease\u2010related risk factors. These results support its use as bridging or long\u2010term treatment, even in advanced stages.<\/jats:p>","DOI":"10.1002\/hem3.70114","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T09:49:52Z","timestamp":1744883392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A German multicenter real\u2010world analysis of talquetamab in 138 patients with relapsed\/refractory multiple myeloma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9682-2601","authenticated-orcid":false,"given":"Jan H.","family":"Frenking","sequence":"first","affiliation":[{"name":"Heidelberg Myeloma Center, Department of Medicine V University Hospital and Medical Faculty Heidelberg Heidelberg University Heidelberg Germany"},{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology German Cancer Research Center (DKFZ) Heidelberg 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