{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:54:44Z","timestamp":1790013284696,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270651"],"award-info":[{"award-number":["81270651"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870131"],"award-info":[{"award-number":["81870131"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100198"],"award-info":[{"award-number":["82100198"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270144"],"award-info":[{"award-number":["82270144"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of <jats:italic>TP53<\/jats:italic> alterations on childhood B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) remains unclear. To investigate the prognostic value of <jats:italic>TP53<\/jats:italic> deletion (<jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup>) and <jats:italic>TP53<\/jats:italic> mutation (<jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>mut<\/jats:italic><\/jats:sup>), this post hoc study used fluorescence in situ hybridization test to detect <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> in 907 newly diagnosed B\u2010ALL patients from a prospective cohort of Chinese Children's Cancer Group ALL\u20102015 trial. Targeted gene sequencing was used to identify <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>mut<\/jats:italic><\/jats:sup> in 342 out of the 907 patients. <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> was detected in 4.4% of patients. The frequency of hypodiploidy was higher in <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> subgroup (7.5% vs. 0.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), but patients with <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> were less likely to have other recurrent genetic abnormalities, including <jats:italic>BCR::ABL1, ETV6::RUNX1, TCF3::PBX1 and KMT2A<\/jats:italic> rearrangements. Univariable and multivariable analyses indicated that <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> was an independent risk factor for overall survival (OS) and disease\u2010free survival (DFS). Furthermore, stratification analysis revealed that <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> was associated with lower 5\u2010year DFS in patients with positive minimal residual disease (MRD) after induction in the intermediate\u2010risk group (0.0% vs. 58.0% [95% confidence interval [CI] 49.2%\u201368.3%], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), suggesting an MRD\u2010dependent pattern. However, somatic <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>mut<\/jats:italic><\/jats:sup> was not associated with poor survival (81.8% [95% CI 61.9%\u2013100.0%] vs. 84.9% [95% CI 81.1%\u201089.0%], <jats:italic>p<\/jats:italic>\u2009=\u20090.971). In summary, <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> may serve as a predictor for poor prognosis in pediatric B\u2010ALL. In particular, children in the intermediate\u2010risk group with positive MRD and <jats:italic>TP53<\/jats:italic><jats:sup><jats:italic>del<\/jats:italic><\/jats:sup> may require more aggressive treatment.<\/jats:p>","DOI":"10.1002\/hem3.70115","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T14:14:37Z","timestamp":1743516877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>TP53<\/i> deletion as an MRD\u2010dependent risk factor in childhood B\u2010ALL: A post hoc analysis from a prospective cohort"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2030-6977","authenticated-orcid":false,"given":"Yangyang","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"An","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4457-7420","authenticated-orcid":false,"given":"Zixi","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-6495","authenticated-orcid":false,"given":"Xiaofan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-558833"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-23-366"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34653-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.247031"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.10.013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000813"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1344839"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.5215"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.263"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.10159"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00274-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.8144"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001307"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2278026"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00328-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21239"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000516654"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22510"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15036"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.152"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.137059"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2023.2195682"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70066-8"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14238"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1299"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.389.3798360"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00822"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00884"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-22-0154"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017755"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01286"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-670729"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.3617"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26066"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.251686"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30810"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:55:33Z","timestamp":1759920933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/hem3.70115"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70115","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2024-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70115"}}