{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:53:03Z","timestamp":1790956383392,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lymphoblastic leukemia (ALL) is the predominant malignancy in pediatric patients, and allogeneic hematopoietic stem cell transplantation (HSCT) plays a critical role in high\u2010risk cases. However, real\u2010world nationwide data comparing the outcomes of conditioning regimens are limited. This nationwide registry\u2010based study analyzed data from 270 Korean pediatric patients with high\u2010risk or relapsed ALL who underwent their first allogeneic HSCT with myeloablative conditioning. Among all analyzed patients, 118 received total body irradiation\u2010based conditioning (MAC\u2010TBI) and 152 received chemotherapy\u2010based conditioning (MAC\u2010Chemotherapy), of whom 96.6% underwent busulfan\u2010based regimens. MAC\u2010TBI recipients were older at diagnosis and at HSCT. No significant differences were observed between groups in neutrophil or platelet engraftment times, or infused CD34+ cell doses. Acute graft\u2010versus\u2010host disease (GVHD) incidences (grades II\u2013IV and III\u2013IV) were comparable, although chronic GVHD incidence tended to be lower in the MAC\u2010Chemotherapy group (21.0% vs. 31.1%, P =\u20090.072). Additionally, the 5\u2010year event\u2010free survival (EFS) rates for MAC\u2010TBI versus MAC\u2010Chemotherapy were 73.7% and 69.8% (P =\u20090.827), respectively; the 5\u2010year overall survival (OS) rates were 76.3% and 80.2% (P =\u20090.941), respectively, indicating that conditioning regimen did not significantly impact survival. Pediatric disease risk index, recent HSCT era, haploidentical donor type, and pre\u2010transplant disease status independently influenced EFS and OS, whereas anti\u2010thymocyte globulin administration significantly improved moderate\u2010to\u2010severe chronic GVHD, leukemia\u2010free survival. This nationwide real\u2010world analysis demonstrated comparable outcomes between myeloablative TBI\u2010based and chemotherapy\u2010based conditioning regimens in pediatric patients with ALL. These findings may inform the development of improved treatment strategies for this patient population.<\/jats:p>","DOI":"10.1002\/hem3.70158","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T05:04:44Z","timestamp":1750136684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparable outcomes for pediatric acute lymphoblastic leukemia patients receiving conditioning with total body irradiation or chemotherapy: A nationwide, Korean registry\u2010based study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-1988","authenticated-orcid":false,"given":"Kyung Taek","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine Seoul National University Cancer Research Institute Seoul Republic of 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Hematology\u2010Oncology, Yonsei Cancer Center Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhl Joo","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology, Yonsei Cancer Center Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keon Hee","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eu Jeen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pusan National University Children's Hospital Pusan National University Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Soo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine Seoul National University Cancer Research Institute Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; AI, National Cancer Center Graduate School of Cancer Science and Policy, Center for Pediatric Cancer National Cancer Center Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Won","family":"Chueh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inje University Haeundae Paik Hospital Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok\u2010Hwan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Chonnam National University Hwasun Hospital Chonnam National University Medical School Hwasun Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Ho","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology, Kyungpook National University Hospital, School of Medicine Kyungpook National University 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