{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:52:58Z","timestamp":1784227978651,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombosis Lymphoma (ThroLy) and Khorana scores have been conceived to predict the thrombotic risk in oncohematologic patients. Currently, there is no univocal indication to perform thromboprophylaxis in classical Hodgkin lymphoma (cHL). We performed a retrospective study to validate scores and risk factors in a cohort of consecutive patients with cHL, treated from 2014 to 2022 outside clinical trials. A total of 470 cHL patients without thromboprophylaxis were included, of whom 57 (12%) experienced a thrombotic event (TE) at 3.3 months (range 1\u201352) from diagnosis. Neither Khorana nor ThroLy score significantly predicted the thrombotic risk. In a multivariate analysis including Throly parameters and other risk factors, an independent prognostic impact on the TE risk was found for bulky disease (3 points), ECOG PS 2\u20134 (2 points), presence of peripherally implanted central venous catheter (2 points), mediastinal involvement (1 point), which were combined in a new risk model (Thro\u2010HL). Low\u2010risk (score 0\u20131; 39%, <jats:italic>n<\/jats:italic>\u2009=\u2009183), intermediate\u2010risk (score 2\u20133; 46%, <jats:italic>n<\/jats:italic>\u2009=\u2009214), and high\u2010risk (score\u2009&gt;\u20093; 15%, <jats:italic>n<\/jats:italic>\u2009=\u200972) patients had a significantly different TE rate, of 2.7%, 16%, and 25% (P\u2009&lt;\u20090.001), respectively. Three\u2010year\u2010thrombotic event\u2010free survival was 97% (CI 95\u2013100) for low\u2010risk and 76% (CI 66\u201386) for high\u2010risk patients (P\u2009&lt;\u20090.0001, Harrel's <jats:italic>C<\/jats:italic>\u2010index\u2009=\u20090.70). Thro\u2010HL could be a promising tool to be validated in larger series.<\/jats:p>","DOI":"10.1002\/hem3.70163","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T09:14:13Z","timestamp":1752398053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting thrombotic risk in patients with classical Hodgkin lymphoma: Thro\u2010HL multicenter study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-9635","authenticated-orcid":false,"given":"Giovanni Manfredi","family":"Assanto","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Alma","sequence":"additional","affiliation":[{"name":"Dipartimento di scienze di laboratorio ed ematologiche, IRCCS Policlinico Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cellini","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED Hematology Unit Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marsili","sequence":"additional","affiliation":[{"name":"GIMEMA Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Maiorana","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Hematology Unit University Hospital Sant' Andrea \u2013 Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Salvatori","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"},{"name":"Hematology Unit S. Maria Goretti Hospital, AUSL Latina Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cenfra","sequence":"additional","affiliation":[{"name":"Hematology Unit S. Maria Goretti Hospital, AUSL Latina Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Otasevic","sequence":"additional","affiliation":[{"name":"Clinic for Hematology University Clinical Center of Serbia Belgrade Serbia"},{"name":"Parexel International Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Antic","sequence":"additional","affiliation":[{"name":"Clinic for Hematology University Clinical Center of Serbia Belgrade Serbia"},{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna Maria","family":"D'Elia","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Hematology Unit University Hospital Sant' Andrea \u2013 Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Annechini","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Ligia","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"},{"name":"Hematology Unit S. Maria Goretti Hospital, AUSL Latina Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Hematology Unit University Hospital Sant' Andrea \u2013 Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-7200","authenticated-orcid":false,"given":"Andrea","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED Hematology Unit Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Piciocchi","sequence":"additional","affiliation":[{"name":"GIMEMA Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hohaus","sequence":"additional","affiliation":[{"name":"Hematology, IRCCS Policlinico Gemelli Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-9533","authenticated-orcid":false,"given":"Ilaria","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Chistolini","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Hematology Sapienza University of Rome \u2013 AOU Policlinico Umberto I Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-08-0686"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02374.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.09.015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-743211"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr392"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30369-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.8197"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051291"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003689"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-258624"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.10.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz168"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24466"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.209114"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006484"},{"key":"e_1_2_11_18_1","article-title":"Khorana score and histotype predicts incidence of early venous thromboembolism in non\u2010Hodgkin lymphomas. 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