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Patients were included in the CART19\u2010BE\u201001 clinical trial and a compassionate use program. Twenty\u2010seven patients with FL were treated. Cytokine release syndrome (any grade) occurred in 55% of patients (4% Grade\u2009\u22653). Only 1 case (4%) of Grade 1 neurotoxicity was documented. The objective response rate was 100% at Day +100 (93% complete response rate), and the 3\u2010year duration of response was 78%. The 3\u2010year progression\u2010free survival and overall survival were 78% and 81%, respectively. All patients developed B\u2010cell aplasia, and the 3\u2010year incidence of B\u2010cell recovery was 17%. In conclusion, patients with R\/R FL treated with var\u2010cel obtained excellent disease control, with prolonged CAR T\u2010cell survival and manageable toxicity. This trial was registered as NCT03144583.<\/jats:p>","DOI":"10.1002\/hem3.70166","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T15:24:06Z","timestamp":1757604246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of the academic anti\u2010CD19 chimeric antigen receptor T\u2010cell product varnimcabtagene autoleucel for the treatment of relapsed\/refractory follicular lymphoma"],"prefix":"10.1002","volume":"9","author":[{"given":"N\u00faria","family":"Mart\u00ednez\u2010Cibri\u00e1n","sequence":"first","affiliation":[{"name":"Department of Haematology Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valent\u00edn","family":"Ortiz\u2010Maldonado","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Cl\u00ednic Barcelona Spain"},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic 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