{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:27:37Z","timestamp":1792056457155,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Venous thromboembolism (VTE) is a frequent complication in patients with multiple myeloma (MM) that leads to increased morbidity, mortality, treatment interruptions, and reduced quality of life. \u0391n Expert Panel Consensus Guideline on behalf of the European Myeloma Network provides evidence\u2010based recommendations for VTE prevention and treatment in patients with MM. Key recommendations include the following:\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>Patient education<\/jats:italic>\n                          . Informing patients about VTE risk and signs\/symptoms of deep vein thrombosis and pulmonary embolism.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>Specialized care<\/jats:italic>\n                          . Establishing a dedicated diagnostic and therapeutic pathway for the prevention and treatment of VTE that occurs in an outpatient setting.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>Risk assessment<\/jats:italic>\n                          . Regular evaluation of VTE risk using validated scores.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>Primary thromboprophylaxis<\/jats:italic>\n                          . Initiating pharmacological thromboprophylaxis with low\u2010molecular\u2010weight heparin (LMWH) or specific direct factor Xa inhibitors (anti\u2010Xa agents) in high\u2010risk patients.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>Prompt diagnosis and treatment<\/jats:italic>\n                          . Early diagnosis of VTE and immediate initiation of antithrombotic therapy with LMWH or anti\u2010Xa agents.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>Secondary prophylaxis<\/jats:italic>\n                          . Personalized long\u2010term antithrombotic therapy based on individual profiles of risk of VTE recurrence or bleeding.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>\n                  <jats:p>By implementing these guidelines, healthcare providers can improve the prevention and treatment of VTE in patients with MM, leading to better clinical outcomes and quality of life.<\/jats:p>","DOI":"10.1002\/hem3.70177","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:43:51Z","timestamp":1756277031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevention and treatment of venous thromboembolism in patients with multiple myeloma: Clinical practice guidelines on behalf of the European Myeloma Network"],"prefix":"10.1002","volume":"9","author":[{"given":"Grigoris","family":"Gerotziafas","sequence":"first","affiliation":[{"name":"Sorbonne University, INSERM UMR_S_938, Saint\u2010Antoine Research Center (CRSA), Research Department \u201cCancer, Vessels, Biology and Therapeutics\u201d (CaVITE), Research Group \u201cCancer\u2013Angiogenesis\u2013Thrombosis and Haemostasis,\u201d Thrombosis Center, University Institute of Cancerology (UIC), Saint Antoine University Hospital Assistance Publique H\u00f4pitaux de Paris (AP\u2010HP) Paris France"},{"name":"VAS\u2010European Independent Foundation in Angiology\/Vascular Medicine Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Fotiou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Plasma Cell Dyscrasias Unit, National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Nijhof","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center Amsterdam The Netherlands"},{"name":"Department of Internal Medicine St. Antonius Hospital Nieuwegein The Netherlands"},{"name":"Department of Hematology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Ay","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Comprehensive Cancer Center Vienna, Division of Hematology and Hemostaseology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Lecumberri","sequence":"additional","affiliation":[{"name":"Hematology Service Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"CIBERCV, Carlos III Health Institute Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Larocca","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Torino, AOU Citt\u00e0 della Salute e della Scienza di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Cook","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trial Research &amp; 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