{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:28:44Z","timestamp":1790980124790,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clonal hematopoiesis (CH) is common in the general population and associated with various health risks, but its prevalence and clinical implications in acute myeloid leukemia (AML) long\u2010term survivors (LTS; \u22655\u2010year survival) are unknown. We analyzed CH in 373 AML\u2010LTS with a median 11.6\u2010year follow\u2010up from diagnosis using a sensitive targeted sequencing assay based on single\u2010molecule molecular inversion probes. CH variants were detected in 61.9% of survivors, with 26% having small\u2010clone CH (SC\u2010CH, variant allele frequency (VAF)\u2009&lt;\u20092%) and 35.9% CH of indeterminate potential (\u22652% VAF). CH was more prevalent in survivors treated with chemotherapy only (75.7%) compared to those who received allogeneic stem cell transplantation (alloSCT, 54.0%) and to age group\u2010matched healthy controls. In chemotherapy\u2010treated survivors, CH prevalence increased with age, whereas in alloSCT recipients, it most closely associated with hematopoietic age (i.e., the sum of donor age and time since transplantation). The variant spectrum also differed by treatment, with <jats:italic>TP53<\/jats:italic> and <jats:italic>PPM1D<\/jats:italic> variants being more common in the chemotherapy group. CH variants \u226510% VAF associated with increased risks of diabetes in alloSCT recipients and secondary neoplasms in chemotherapy\u2010treated survivors. This study provides insights into the high prevalence and potential clinical relevance of CH in AML\u2010LTS.<\/jats:p>","DOI":"10.1002\/hem3.70183","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:33:32Z","timestamp":1753360412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clonal hematopoiesis in AML long\u2010term survivors: Risk factors and clinical consequences"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8514-5500","authenticated-orcid":false,"given":"Simon M.","family":"Krau\u00df","sequence":"first","affiliation":[{"name":"Department of Hematology, Cell Therapy, Hemostaseology and Infectiology University of Leipzig Medical Center Leipzig 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