{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:59:32Z","timestamp":1792245572998,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Natural killer (NK)\/T\u2010cell lymphomas (NKTCLs) are rare, aggressive lymphomas prevalent in East Asia and South America. Despite improvements, largely due to asparaginase\u2010based therapies, outcomes for advanced disease remain poor, and the role of autologous stem cell transplantation (auto\u2010HCT) remains controversial. This study evaluated real\u2010world outcomes of auto\u2010HCT in NKTCL patients across Asia and Europe. We included 130 adult NKTCL patients undergoing auto\u2010HCT between 2011 and 2022 using data from the European Society for Blood and Marrow Transplantation (EBMT) registry and South Korean registry data. Median age was 51.3 years; 66.9% were male. Most patients (95.1%) had an Eastern Cooperative Oncology Group (ECOG) score 0\u20131; 65.3% had Stage III\u2013IV disease. One prior therapy line was reported in 53.1%, and \u22652 lines in 46.9%. Asparaginase\u2010based regimens were used in 79.5% pretransplant. Responses at auto\u2010HCT included complete (59.7%), partial (27.9%) remission, and stable\/progressive disease (12.4%). Epstein\u2013Barr virus (EBV)\u2010DNA in the peripheral blood was reported in 37.3%. With a median follow\u2010up of 4.6 years, 3\u2010year overall survival (OS) and progression\u2010free survival (PFS) were 63.8% and 47.6%. Relapse and NRM rates at 3 years were 46.7% and 5.7%. Patients in complete remission had improved 3\u2010year OS (75.2%) compared to PR (52.8%) and stable\/progressive disease (32.0%) (P\u2009=\u20090.007). Detectable EBV\u2010DNA in the blood at auto\u2010HCT was associated with poor outcomes (3\u2010year OS: 26.7% vs. 78.1% in patients with undetectable EBV\u2010DNA; P\u2009&lt;\u20090.0001). Patients achieving complete remission and undetectable EBV\u2010DNA in the blood before auto\u2010HCT had a favorable survival, suggesting auto\u2010HCT may be a treatment option in selected high\u2010risk patients. This is the largest multinational cohort evaluating prognostic factors for auto\u2010HCT for NKTCL.<\/jats:p>","DOI":"10.1002\/hem3.70184","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T09:19:38Z","timestamp":1755249578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Autologous stem cell transplantation in NK\/T\u2010cell lymphoma: Prognostic impact of EBV\u2010DNA in a multinational cohort\u2014A study by the EBMT Lymphoma Working Party"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0442-3521","authenticated-orcid":false,"given":"Philipp","family":"Berning","sequence":"first","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pneumology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Ngoya","sequence":"additional","affiliation":[{"name":"European Society for Blood and Marrow Transplantation Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine, Samsung Medical Center Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-1729","authenticated-orcid":false,"given":"Evgenii","family":"Shumilov","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology, Oncology and Pneumology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depei","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1824-5247","authenticated-orcid":false,"given":"Haiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cairoli","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Oncology University Hospital of Lausanne (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Hematology ASST Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Dachy","sequence":"additional","affiliation":[{"name":"Hematology Department Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Gounot","sequence":"additional","affiliation":[{"name":"Service H\u00e9matologie H\u00f4pital Henri Mondor Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Wilke","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, Goethe University Frankfurt Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Scheid","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne University of Cologne Cologne 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