{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:16:02Z","timestamp":1785453362873,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Venetoclax has been combined with intensive chemotherapy regimens in the treatment of acute myeloid leukemia (AML). We aimed to investigate the safety and efficacy of venetoclax combined with full\u2010dose CPX\u2010351 (CPX\u2009+\u2009VEN) in newly diagnosed (ND) AML. Seventeen patients with a median age of 59 years (range, 43\u201369) were treated; 71% had secondary AML, 47% had prior hypomethylating agent (HMA) exposure, 59% had myelodysplastic syndrome (MDS)\u2010related (MR) mutations, 47% had complex karyotype, and 29% were\n                    <jats:italic>TP53<\/jats:italic>\n                    mutated. The overall response rate (ORR) was 82% (95% CI, 57\u201396) with a composite complete remission rate (CRc) of 71% (95% CI, 50\u201393). Patients with MR mutations had an ORR of 100% (95% CI, 69\u2013100), including a CRc of 90% (95% CI, 55\u2013100). Patients with prior HMA exposure had a CRc of 63% (95% CI, 24\u201391). With a median follow\u2010up time of 11.8 months, the median overall survival (OS) was 12.8 months (95% CI, 5\u2013NE) with a 2\u2010year OS of 34% (95% CI, 10\u201361). Patients with MR mutations had a median OS of 17.9 months versus 5.1 months in patients without MR mutations (P\u2009=\u20090.039). Twelve (86%) of 14 responding patients proceeded to stem cell transplant (SCT); the median recurrence\u2010free survival and OS landmarked from date of SCT were 14.7 months (95% CI, 1\u201332) and 14.7 months (95% CI, 4\u201325), respectively. The 4\u2010week mortality was 0% and the 8\u2010week mortality was 17%. The most common adverse events were related to myelosuppression. CPX\u2009+\u2009VEN resulted in high remission rates and enabled progression to allogenic SCT for the majority of a highly adverse group of ND AML patients.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70214","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:57:31Z","timestamp":1761141451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Phase 2 study of CPX\u2010351 in combination with venetoclax in patients with newly diagnosed high\u2010risk acute myeloid leukemia"],"prefix":"10.1002","volume":"9","author":[{"given":"Wei\u2010Ying","family":"Jen","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-4341","authenticated-orcid":false,"given":"Jennifer","family":"Croden","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Almanza\u2010Huante","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesid","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Masarova","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres E.","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Pierce","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bataller","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas 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