{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:31:55Z","timestamp":1788201115065,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Relapse following CD19\u2010targeting chimeric antigen receptor T\u2010cell therapy (CD19\u2010CAR) remains a major barrier to long\u2010term cure in relapsed\/refractory B\u2010cell acute lymphoblastic leukemia, with nearly 50% of patients relapsing within 6 months. Early B\u2010cell recovery (BCR), as detected by the re\u2010emergence of CD19\u2010positive cells, has been strongly associated with relapse risk and serves as a surrogate marker for loss of CAR T\u2010cell persistence. However, clinical use of BCR is hindered by variability in monitoring practices, including inconsistent definitions, timing, and measurement across institutions. To address this gap, we convened an international working group of pediatric cellular therapy experts to establish a consensus definition for BCR. Our collaborative effort outlines standardized criteria for BCR assessment aimed at improving comparability across studies and guiding post\u2010CAR T\u2010cell surveillance strategies.<\/jats:p>","DOI":"10.1002\/hem3.70247","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:07:51Z","timestamp":1762938471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Harmonization on defining B\u2010cell recovery post CD19\u2010CAR T\u2010cell therapy in B\u2010cell acute lymphoblastic leukemia: An international consensus statement"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-2918","authenticated-orcid":false,"given":"Adam","family":"Lamble","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Seattle Children's Hospital University of Washington Seattle Washington United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra D.","family":"Bohling","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Pathology Seattle Children's Hospital University of Washington Seattle Washington United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine, Division of Pediatric Hematology\/Oncology\/Stem Cell Transplantation and Regenerative Medicine Stanford California United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee C.","family":"Talleur","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital Memphis Tennessee United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin O.","family":"McNerney","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology and Stem Cell Transplantation Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital Memphis Tennessee United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Haematology UCL Great Ormond Street Institute of Child Health London United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology National Cancer Institute, NIH Bethesda Maryland United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance M.","family":"Yuan","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology National Cancer Institute, NIH Bethesda Maryland United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Jacoby","sequence":"additional","affiliation":[{"name":"The Edmond and Lily Safra Children's Hospital, Sheba Medical Center and Tel Aviv University Division of Pediatric Hematology and Oncology Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Baruchel","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Immunology Department Robert\u2010Debr\u00e9 Hospital (Assistance Publique\u2010H\u00f4pitaux de Paris [APHP]) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ghorashian","sequence":"additional","affiliation":[{"name":"Department of Haematology UCL Great Ormond Street Institute of Child Health London United\u00a0Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Pulsipher","sequence":"additional","affiliation":[{"name":"Intermountain Primary Children's Hospital, Spencer Fox Eccles School of Medicine at the University of Utah, Division of Hematology and Oncology Huntsman Cancer Institute Salt Lake City Utah United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liora","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine, Division of Pediatric Hematology\/Oncology\/Stem Cell Transplantation and Regenerative Medicine Stanford California United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital Memphis Tennessee United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirali N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch, Center for Cancer Research National Cancer Institute Bethesda Maryland United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00642"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01076"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0095"},{"key":"e_1_2_15_5_1","unstructured":"GranthamJ ThomasC DavidsonJ NuttJ HuangJ. Development of a multiplexed quantitative PCR assay for CD19\u2010directed CAR\u2010T cell persistence monitoring. Tandem Meetings;2023."},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-786129"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125423"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-769208"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03458"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000692"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006293"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024517"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011168"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024012885"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.10.003"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.24507"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21747"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2498"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903370346"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.1.9"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.016"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1280580"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100596"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01027-6"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-357-2_8"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21854"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13548"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2012.02671.x"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000463"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21239"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.08.030"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007423"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.08.009"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3198"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01740-9"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.02.012"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148820"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-63146-2_26"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2711-1"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008981"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0184-6"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.2991\/chi.d.190219.001"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21168-6"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01281-7"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010461"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005564"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00530-z"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15102767"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16339"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-633685"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009856"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.10.004"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023699"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00084"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:39:40Z","timestamp":1765186780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hem3.70247"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70247","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70247"}}