{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:43:06Z","timestamp":1788158586645,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Health\u2010related quality of life (HRQoL) of patients with myeloproliferative neoplasms (MPNs) may be impaired across several domains. In this multicenter observational study, we evaluated HRQoL and symptoms in a cohort of MPN patients with validated measures, including the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire\u2010Core 30 (EORTC QLQ\u2010C30), the Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score (MPN\u2010SAF TSS), and the Functional Assessment of Chronic Illness Therapy\u2010Fatigue Scale (FACIT\u2010Fatigue) questionnaire. The primary objective was to compare the HRQoL profile of patients, by disease subtype, with that of the general population according to the EORTC QLQ\u2010C30. A total of 572 patients with essential thrombocythemia (ET,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009228), polycythemia vera (PV,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009207), and myelofibrosis (MF,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009137) were assessed. Worse statistically and clinically significant differences were observed for role functioning (ET: \u2206\u2009=\u20098.9, P\u2009&lt;\u20090.001; PV: \u2206\u2009=\u200911, P\u2009&lt;\u20090.001; MF: \u2206\u2009=\u200916.7, P\u2009&lt;\u20090.001) and fatigue (ET: \u2206\u2009=\u20095, P\u2009&lt;\u20090.001; PV: \u2206\u2009=\u20098.3, P\u2009&lt;\u20090.001; MF: \u2206\u2009=\u200911.5, P\u2009&lt;\u20090.001) in all three diagnostic groups. However, patients with MF also reported impairments in other important health domains. Fatigue was the most frequently reported and burdensome symptom, with greater severity correlating with a broader and more complex array of associated symptoms. Our analysis also revealed a substantial underestimation of symptoms by treating hematologists in paired physician\u2013patient reports. Current findings may help to disentangle specific HRQoL limitations and symptomatology experienced by patients with MPNs, and underscore the importance of incorporating patient\u2010reported outcomes into routine practice to better reflect the patient's perspective of the disease and treatment\u2010related burden.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70274","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T03:10:21Z","timestamp":1766977821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Health\u2010related quality of life and symptom profile of patients with\n                    <i>BCR::ABL1<\/i>\n                    \u2010negative myeloproliferative neoplasms: Real\u2010world evidence from the GIMEMA\u2010PROPHECY observational study"],"prefix":"10.1002","volume":"9","author":[{"given":"Giovanni","family":"Caocci","sequence":"first","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS Brotzu, Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-2936","authenticated-orcid":false,"given":"Alessandro","family":"Costa","sequence":"additional","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS Brotzu, Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-5668","authenticated-orcid":false,"given":"Francesca","family":"Palandri","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-284X","authenticated-orcid":false,"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[{"name":"CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms University of Florence, AOU Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Patriarca","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Translational Medicine University of Eastern Piedmont and Maggiore Charity Hospital Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-0812","authenticated-orcid":false,"given":"Alessandra","family":"Iurlo","sequence":"additional","affiliation":[{"name":"Hematology Division Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Tieghi","sequence":"additional","affiliation":[{"name":"Department of Hematology Azienda Unit\u00e0 Sanitaria Locale (AUSL)\u2010IRCCS\u2010Reggio Emilia Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Abruzzese","sequence":"additional","affiliation":[{"name":"Hematology Unit S. Eugenio Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Baldi","sequence":"additional","affiliation":[{"name":"Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center and Health Outcomes Research Unit Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Institute of Haematology Catholic University, \u201cA. Gemelli\u201d Academic Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloise","family":"Beggiato","sequence":"additional","affiliation":[{"name":"Hematology AOU Citt\u00e0 della Salute e della Scienza di Torino\u2010Presidio Ospedaliero Molinette Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Unit University Hospital of Alessandria Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fava","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Tomassetti","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Oncology and Hematology Infermi Hospital Rimini Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Rumi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Fozza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy University of Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Luppi","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Medical and Surgical Sciences University of Modena and Reggio Emilia, AOU Modena Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pane","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation University Hospital Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bigliardi","sequence":"additional","affiliation":[{"name":"Oncology Unit Azienda Unit\u00e0 Sanitaria Locale Modena, Area Sud Sede di Sassuolo Sassuolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[{"name":"Hematology Division and Bone Marrow Transplant Unit San Gerardo Hospital, ASST Monza Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center and Health Outcomes Research Unit Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Mulas","sequence":"additional","affiliation":[{"name":"Hematology Unit, Businco Hospital, ARNAS Brotzu, Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Fazi","sequence":"additional","affiliation":[{"name":"Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center and Health Outcomes Research Unit Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vignetti","sequence":"additional","affiliation":[{"name":"Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center and Health Outcomes Research Unit Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-0730","authenticated-orcid":false,"given":"Alessandro Maria","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms University of Florence, AOU Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-5166","authenticated-orcid":false,"given":"Fabio","family":"Efficace","sequence":"additional","affiliation":[{"name":"Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center and Health Outcomes Research Unit Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22365"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2208-2"},{"key":"e_1_2_10_5_1","unstructured":"US Food and Drug Administration. 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