{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:31:30Z","timestamp":1790875890600,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autologous stem cell transplantation (auto\u2010SCT) is an established treatment for peripheral T\u2010cell lymphoma (PTCL) to consolidate first remission and for patients with relapsed\/refractory (r\/r) disease. We aimed to examine the outcomes of patients with PTCL NOS, AITL, and ALK\u2010negative ALCL undergoing auto\u2010SCT between 2010 and 2022 and reported to EBMT. Adult patients with major T\u2010cell entities who had received auto\u2010SCT either up\u2010front or for r\/r disease were included. 2082 patients underwent up\u2010front and 1249 salvage auto\u2010SCT. Three\u2010year progression\u2010free (PFS) and overall survival (OS) after up\u2010front auto\u2010SCT were 55.2% and 73.1%. For r\/r patients, 3\u2010year PFS and OS were 42.6% and 59.5%. In multivariate analysis, male patients, histology other than ALK\u2010negative ALCL, non\u2010CR, and higher age at auto\u2010SCT showed significantly lower PFS and OS after both, up\u2010front and salvage auto\u2010SCT, mostly reflecting the higher relapse incidence for these patients. Major outcomes did not significantly change when the analyses were restricted to the patients with PET\u2010based response at auto\u2010SCT (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092062). Auto\u2010SCT demonstrated excellent outcomes when used up\u2010front and surprisingly good results in salvage settings. Patients with ALK\u2010negative ALCL survived significantly better than patients with PTCL NOS or AITL. Male gender, higher age, and non\u2010CR at auto\u2010SCT were associated with poor outcomes. Overall, auto\u2010SCT is a valid treatment option in T\u2010cell lymphoma where targeted therapies still play a limited role.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70313","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:20:13Z","timestamp":1772994013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Autologous stem cell transplantation in major T\u2010cell lymphoma entities: An analysis by the EBMT Lymphoma Working Party"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-1729","authenticated-orcid":false,"given":"Evgenii","family":"Shumilov","sequence":"first","affiliation":[{"name":"Department of Medicine A, Hematology and Oncology University Hospital of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Ngoya","sequence":"additional","affiliation":[{"name":"European Society for Blood and Marrow Transplantation, Paris Study Unit, H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Berning","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology and Oncology University Hospital of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Khvedelidze","sequence":"additional","affiliation":[{"name":"European Society for Blood and Marrow Transplantation, Paris Study Unit, H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina","family":"Serroukh","sequence":"additional","affiliation":[{"name":"Department of Hematology, Erasmus Medical Center Cancer Institute University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Wondergem","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Centers, Cancer Center Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cwynarski","sequence":"additional","affiliation":[{"name":"University College London Hospital's NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Thurner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Saarland University Medical School Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn E.","family":"Wahlin","sequence":"additional","affiliation":[{"name":"Lymphoma section, Hematology Unit Karolinska Universitetssjukhuset Stockholm Sweden"},{"name":"Department of Medicine at Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zeiser","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine Freiburg University Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Hazenberg","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen, University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Royal Marsden Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Remenyi","sequence":"additional","affiliation":[{"name":"Department of Hematology Central Hospital of Southern Pest, National Institute of Hematology and Infectious Diseases Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Netelenbos","sequence":"additional","affiliation":[{"name":"Haga Teaching Hospital, Department of Hematology the Hague  the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Lenhoff","sequence":"additional","affiliation":[{"name":"Department of Hematology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tournilhac","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Clermont\u2010Ferrand University Hospital, University Clermont Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Wilson","sequence":"additional","affiliation":[{"name":"Blood and Bone Marrow Transplantation Programme Cardiff and Vale University Health Board Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aloysius","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Hematology Singapore General Hospital and National Cancer Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology and Oncology University Hospital of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Wulf","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology University Hospital of Goettingen Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Helios Clinic Berlin\u2010Buch Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dreger","sequence":"additional","affiliation":[{"name":"Department Medicine V University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sureda","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department, Institut Catal\u00e0 d'Oncologia \u2010 L'Hospitalet, IDIBELL Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghandi","family":"Damaj","sequence":"additional","affiliation":[{"name":"Centre Hospitalier\u2010Universitaire, Institut d'H\u00e9matologie, Universit\u00e9 de Caen Normandie, CNRS, Normandie Universit\u00e9 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-4997","authenticated-orcid":false,"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Program, Department of Internal Medicine American University of Beirut Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Medicine A, Hematology and Oncology University Hospital of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.126300"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.213512"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-270785"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.2719"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0838-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.0188"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.04.021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.4870"},{"key":"e_1_2_10_12_1","unstructured":"NCCN Guidelines for T\u2010Cell Lymphomas. Version 1.2025. Accessed on 14 June 2025.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/t-cell.pdf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(25)00073-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.63"},{"key":"e_1_2_10_16_1","first-page":"2646","article-title":"A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first\u2010line therapy in poor\u2010risk peripheral T\u2010NHL","volume":"137","author":"Schmitz N","year":"2021","journal-title":"Blood"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.79"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00554"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(24)00102-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00589-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00503-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01545-w"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.0188"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.12.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003971"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hem3.70313","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:47:42Z","timestamp":1782218862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/hem3.70313"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70313","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70313"}}