{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:09:07Z","timestamp":1789758547802,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prognosis in therapy\u2010related acute myeloid leukemia (T\u2010AML) remains poor, but understanding outcomes with venetoclax (VEN)\u2010based therapy is relevant. We retrospectively analyzed 317 adult patients with newly diagnosed T\u2010AML focusing on lower intensity therapy (LIT) VEN\u2010containing regimens. Patients with an antecedent myeloid disorder before AML diagnosis were excluded. The median age was 69 years (range 21\u201392); 50% evaluated patients had a complex karyotype, and 40% evaluated patients had a\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation. Composite complete response rates were higher with LIT\u2009+\u2009VEN compared to LIT (58% vs. 40%, P\u2009=\u20090.003) but were similar in intensive chemotherapy (IC)\u2009+\u2009VEN versus IC alone (68% vs. 61%, P\u2009=\u20090.59). Rates of allogeneic hematopoietic stem cell transplantation (HSCT) were higher in VEN\u2010treated patients: 22% versus 7% in LIT\u2009+\u2009VEN and LIT, and 64% versus 39% in IC\u2009+\u2009VEN and IC, respectively. At a median follow\u2010up of 46.4 months, the median relapse\u2010free survival (RFS) and overall survival (OS) of the full cohort were 7.2 and 8.4 months, respectively. Among LIT\u2009+\u2009VEN\u2010treated patients, the median RFS and OS were 8.0 and 9.0 months, respectively; in patients with ELN2024 favorable risk, the median OS was 25.4 months (1\u2010year OS rate of 62%), compared to 9.4 months in the intermediate (\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010ITD and\/or\n                    <jats:italic>RAS<\/jats:italic>\n                    mutated) and 4.8 months in the adverse risk (\n                    <jats:italic>TP53<\/jats:italic>\n                    mutated) group. Patients with\n                    <jats:italic>NPM1<\/jats:italic>\n                    and\/or\n                    <jats:italic>IDH<\/jats:italic>\n                    mutations had 2\u2010year OS over 60%. On multivariate analysis in LIT\u2009+\u2009VEN\u2010treated patients, HSCT and\n                    <jats:italic>NPM1<\/jats:italic>\n                    \/\n                    <jats:italic>IDH2<\/jats:italic>\n                    mutations were favorable, while\n                    <jats:italic>TP53<\/jats:italic>\n                    \/\n                    <jats:italic>RAS<\/jats:italic>\n                    mutations were associated with inferior survival. VEN\u2010based therapy improves outcomes in patients with T\u2010AML, especially in those with VEN\u2010sensitizing genomics and receiving an HSCT.\n                  <\/jats:p>","DOI":"10.1002\/hem3.70317","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:24:03Z","timestamp":1770895443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of therapy\u2010related non\u2010core binding factor acute myeloid leukemia with venetoclax\u2010based therapies"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-2567","authenticated-orcid":false,"given":"Jayastu","family":"Senapati","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-4341","authenticated-orcid":false,"given":"Jennifer","family":"Croden","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naval G.","family":"Daver","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan M.","family":"Kadia","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Borthakur","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas James","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-1279","authenticated-orcid":false,"given":"Jennifer","family":"Marvin\u2010Peek","sequence":"additional","affiliation":[{"name":"Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-3562","authenticated-orcid":false,"given":"Hussein A.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithviraj","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-4806","authenticated-orcid":false,"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanam","family":"Loghavi","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Shpall","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation &amp; Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Ramdial","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation &amp; Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday R.","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation &amp; Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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