{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:44:40Z","timestamp":1777398280624,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1157871"],"award-info":[{"award-number":["APP1157871"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2033152"],"award-info":[{"award-number":["APP2033152"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000926","name":"Leukaemia Foundation","doi-asserted-by":"publisher","award":["1184963"],"award-info":[{"award-number":["1184963"]}],"id":[{"id":"10.13039\/501100000926","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001184","name":"Cure Cancer Australia Foundation","doi-asserted-by":"publisher","award":["1184963"],"award-info":[{"award-number":["1184963"]}],"id":[{"id":"10.13039\/501100001184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["1184963"],"award-info":[{"award-number":["1184963"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1002\/hem3.70355","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:40:21Z","timestamp":1774968021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological inhibition of sclerostin protects bone from B\u2010cell acute lymphoblastic leukemia\u2010mediated destruction"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-8566","authenticated-orcid":false,"given":"Vincent","family":"Kuek","sequence":"first","affiliation":[{"name":"Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia"},{"name":"School of Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Oommen","sequence":"additional","affiliation":[{"name":"Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris N.","family":"Economides","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc. Tarrytown New York United\u00a0States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-9071","authenticated-orcid":false,"given":"Richard B.","family":"Lock","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-7778","authenticated-orcid":false,"given":"Sebastien","family":"Malinge","sequence":"additional","affiliation":[{"name":"Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia"},{"name":"School of Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-4075","authenticated-orcid":false,"given":"Rishi S.","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"},{"name":"Department of Clinical Haematology Oncology, Blood and Marrow Transplantation, Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-5288","authenticated-orcid":false,"given":"Laurence C.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Leukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"School of Diagnostic and Therapeutic Sciences Curtin University Perth Western Australia Australia"},{"name":"Curtin Medical Research Institute Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090202"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.4830"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba5942"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29183"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-025-01239-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707876115"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0144-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0245-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-517219"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2789"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.152"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01072-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.06.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.06.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011557"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5530650"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13885"},{"issue":"11","key":"e_1_2_8_20_1","first-page":"3775","article-title":"Serpina3n, dominantly expressed in female osteoblasts, suppresses the phenotypes of differentiated osteoblasts in mice","volume":"159","author":"Ishida M","year":"2018","journal-title":"Endocrinology"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.745911"}],"container-title":["HemaSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hem3.70355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hem3.70355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:12:56Z","timestamp":1777371176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hem3.70355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/hem3.70355"],"URL":"https:\/\/doi.org\/10.1002\/hem3.70355","archive":["Portico"],"relation":{},"ISSN":["2572-9241","2572-9241"],"issn-type":[{"value":"2572-9241","type":"print"},{"value":"2572-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"2025-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70355"}}