{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:03:21Z","timestamp":1780045401745,"version":"3.53.1"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HemaSphere"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Relapse after chimeric antigen receptor (CAR) T\u2010cell therapy in large B\u2010cell lymphoma (LBCL) is associated with a dismal prognosis. Although Phase 3 trials have established CAR T\u2010cells as standard second\u2010line (2L) therapy, outcomes and optimal management after relapse in this setting remain unknown because no real\u2010world data are currently available. We conducted a multicenter retrospective study using the French DESCAR\u2010T registry, including patients with LBCL who relapsed after 2L CAR T\u2010cell therapy with axicabtagene ciloleucel or lisocabtagene maraleucel. The objective was to describe postrelapse treatments, outcomes, and prognostic factors. Among the 893 patients treated with 2L CAR T\u2010cells, 297 (33%) relapsed and were analyzed. Median time to relapse was 2.7 months, with 35% of these relapses occurring within 2 months. Among the 231 treated patients, bispecific antibody (BsAb)\u2010based regimens were the most common type of salvage therapy (65%). The overall response rate after relapse was 39.1%, with a complete response rate of 27.6%. Notably, despite the use of BsAb\u2010based therapy in 65% of patients, the median overall survival (OS2) after relapse was only 6.5 months (median progression\u2010free survival [PFS2]: 3.4 months). Patients treated with BsAb monotherapy achieved a median OS of 7.1 months. Multivariate analysis revealed that early relapse (&lt;6 months), an Eastern Cooperative Oncology Group (ECOG)\u2009\u2265\u20092, and an elevated C\u2010reactive protein (\u226530\u2009mg\/L) were independently associated with poor OS. This study represents the first real\u2010world analysis of outcomes after relapse following 2L CAR T\u2010cell therapy. Despite the more frequent incorporation of BsAbs into the therapeutic landscape, overall prognosis and treatment efficacy remain dismal, highlighting the urgent need for innovative therapeutic strategies and dedicated prospective trials in this emerging double\u2010refractory population.<\/jats:p>","DOI":"10.1002\/hem3.70356","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:41:06Z","timestamp":1778085666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and salvage strategies for large B\u2010cell lymphoma progressing after second\u2010line CAR T\u2010cell therapy: A DESCAR\u2010T study from the LYSA group"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-822X","authenticated-orcid":false,"given":"Pierre","family":"Sesques","sequence":"first","affiliation":[{"name":"CHU de Lyon Lyon 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